Anti-IRAK Antibody | Boster Immunoleader PA2183 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-IRAK Antibody

catalog :

PA2183

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

publications citing this reagent :

Liu M, Wang Y, Qian C, Li H. Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. Int J Mol Med. 2014;34:1492-504 pubmed publisher

more info or order :

Boster Immunoleader product webpage

product information

Availability :

info changed 20150327

Product Name :

Anti-IRAK Antibody

Catalog Number :

PA2183

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Interleukin-1 receptor-associated kinase 1(IRAK1) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human IRAK(18-37aa FLYEVPPWVMCRFYKVMDAL), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Interleukin-1 receptor-associated kinase 1, also called IRAK1, is an enzyme that in humans is encoded by the IRAK1 gene. By radiation hybrid analysis, this gene is mapped to chromosome Xq28. Serine/threonine-protein kinase plays a critical role in initiating innate immune response against foreign pathogens. This gene involved in Toll-like receptor(TLR) and IL-1R signaling pathways. This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor(IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.

Reference :

1. Chassin, C., Kocur, M., Pott, J., Duerr, C. U., Gutle, D., Lotz, M., Hornef, M. W. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 8: 358-368, 2010. 2. Jacob, C. O., Zhu, J., Armstrong, D. L., Yan, M., Han, J., Zhou, X. J., Thomas, J. A., Reiff, A., Myones, B. L., Ojwang, J. O., Kaufman, K. M., Klein-Gitelman, M., and 17 others. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc. Nat. Acad. Sci. 106: 6256-6261, 2009.

Gene Name :

IRAK1

Protein Name :

Interleukin-1 receptor-associated kinase 1

Gene Full Name :

interleukin-1 receptor-associated kinase 1

Synonyms :

Il1rak antibody Interleukin 1 receptor associated kinase 1 antibody Interleukin-1 receptor-associated kinase 1 antibody IRAK antibody IRAK-1 antibody Irak1 antibody IRAK1_HUMAN antibody mPLK antibody OTTHUMP00000026014 antibody OTTHUMP00000026015 antibody OTTHUMP00000026020 antibody OTTHUMP00000180621 antibody Pelle antibody Pelle homolog antibody Pelle-like protein kinase antibody Plpk antibody

Uniprot ID :

P51617

more info or order :

Boster Immunoleader product webpage