Anti-HYAL1 Antibody | Boster Immunoleader PA2181-2 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-HYAL1 Antibody

catalog :

PA2181-2

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

mouse

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-HYAL1 Antibody

Catalog Number :

PA2181-2

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Hyaluronidase-1(HYAL1) detection. Tested with WB in mouse.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1(434-450aa LKDRAQMAMKFRCRCYR), different from the related rat sequence by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Reference :

1. Csoka, A. B., Frost, G. I., Heng, H. H. Q., Scherer, S. W., Mohapatra, G., Stern, R. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics 48: 63-70, 1998. Note: Erratum: Genomics 84: 227 only, 2004. 2. Martin, D. C., Atmuri, V., Hemming, R. J., Farley, J., Mort, J. S., Byers, S., Hombach-Klonisch, S., Csoka, A. B., Stern, R., Triggs-Raine, B. L. A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum. Molec. Genet. 17: 1904-1915, 2008. Note: Erratum: Hum. Molec. Genet. 17: 2919 only, 2008.

Gene Name :

HYAL1

Protein Name :

Hyaluronidase-1

Gene Full Name :

hyaluronoglucosaminidase 1

Synonyms :

HYAL 1 antibody Hyal-1 antibody HYAL1 antibody HYAL1_HUMAN antibody Hyaluronidase 1 antibody Hyaluronidase-1 antibody Hyaluronoglucosaminidase 1 antibody Hyaluronoglucosaminidase-1 antibody Hyaluronoglucosaminidase1 antibody LUCA 1 antibody LUCA-1 antibody LUCA1 antibody Lung carcinoma protein 1 antibody MGC45987 antibody NAT6 antibody Plasma hyaluronidase antibody Tumor suppressor LUCA 1 antibody

Uniprot ID :

Q91ZJ9

more info or order :

Boster Immunoleader product webpage