Anti-CCR3 Antibody | Boster Immunoleader PA2176 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CCR3 Antibody

catalog :

PA2176

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

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product information

Product Name :

Anti-CCR3 Antibody

Catalog Number :

PA2176

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for C-C chemokine receptor type 3(CCR3) detection. Tested with WB, IHC-P, ICC in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P,ICC

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Immunocytochemistry :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human CCR3(1-20aa MTTSLDTVETFGTTSYYDDV).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P) and ICC.

Background :

C-C chemokine receptor type 3, also called CCR3 or CKR3 is a protein that in humans is encoded by the CCR3 gene. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. This receptor binds and responds to a variety of chemokines, including eotaxin(CCL11), eotaxin-3(CCL26), MCP-3(CCL7), MCP-4(CCL13), and RANTES(CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. Alternatively spliced transcript variants have been described.

Reference :

1. Blanchard, C., Wang, N., Stringer, K. F., Mishra, A., Fulkerson, P. C., Abonia, J. P., Jameson, S. C., Kirby, C., Konikoff, M. R., Collins, M. H., Cohen, M. B., Akers, R., Hogan, S. P., Assa'ad, A. H., Putnam, P. E., Aronow, B. J., Rothenberg, M. E. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J. Clin. Invest. 116: 536-547, 2006. 2. Takeda, A., Baffi, J. Z., Kleinman, M. E., Cho, W. G., Nozaki, M., Yamada, K., Kaneko, H., Albuquerque, R. J. C., Dridi, S., Saito, K., Raisler, B. J., Budd, S. J., and 15 others. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature 460: 225-230, 2009.

Gene Name :

CCR3

Protein Name :

C-C chemokine receptor type 3

Gene Full Name :

chemokine(C-C motif) receptor 3

Synonyms :

B Chemokine Receptor antibody b-chemokine receptor antibody C C chemokine receptor type 3 antibody C C CKR 3 antibody C-C chemokine receptor type 3 antibody C-C CKR-3 antibody CC Chemokine Receptor 3 antibody CC chemokine receptor type 3 antibody CC CKR 3 antibody CC R3 antibody CC-CKR-3 antibody CCCKR3 antibody CCR 3 antibody CCR-3 antibody CCR3 antibody CCR3_HUMAN antibody CD 193 antibody CD193 antibody CD193 antigen antibody Chemokine(C C motif) receptor 3 antibody chemokine(C-C motif) receptor 3 antibody Chemokine(CC) Receptor 1 Like 2 antibody Chemokine CC Motif Receptor 3 antibody Chemokine receptor 3 antibody CK R3 antibody CKR 3 antibody CKR3 antibody CMKB R3 antibody CMKBR 3 antibody CMKBR1L2 antibody CMKBR3 antibody Eosinophil CC Chemokine Receptor 3 antibody Eosinophil Eotaxin Receptor antibody Eotaxin Receptor antibody Macrophage inflammatory protein 1 alpha receptor like 2 antibody Macrophage Inflammatory Protein1 Alpha Receptor Like 2 antibody MGC102841 antibody MIP1 Alpha RL2 antibody

Uniprot ID :

P51677

more info or order :

Boster Immunoleader product webpage