Anti-RGS14 Antibody | Boster Immunoleader PA2163 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-RGS14 Antibody

catalog :

PA2163

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-RGS14 Antibody

Catalog Number :

PA2163

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Regulator of G-protein signaling 14(RGS14) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human RGS14(359-372aa CTVLADQEVRLENR), identical to the related mouse and rat sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Regulator of G-protein signaling 14, also called RGS14, is a protein that in humans is encoded by the RGS14 gene. This gene encodes a member of the regulator of G-protein signaling family. By genomic sequence analysis, this gene is mapped to chromosome 5q35.3. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein(GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

Reference :

1. Kimple, R. J., Kimple, M. E., Betts, L., Sondek, J., Siderovski, D. P. Structural determinants for GoLoco-induced inhibition of nucleotide release by G-alpha subunits. Nature 416: 878-881, 2002. 2. Traver, S., Bidot, C., Spassky, N., Baltauss, T., de Tand, M.-F., Thomas, J.-L., Zalc, B., Janoueix-Lerosey, I., de Gunzburg, J. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of G-alpha-0. Biochem. J. 350: 19-29, 2000.

Gene Name :

RGS14

Protein Name :

Regulator of G-protein signaling 14

Gene Full Name :

regulator of G-protein signaling 14

Synonyms :

Highly similar to rap1/rap2 interacting protein antibody OTTHUMP00000223586 antibody OTTHUMP00000223587 antibody Regulation of G protein signaling 14 antibody Regulator of G protein signaling 14 antibody Regulator of G protein signalling 14 antibody Regulator of G-protein signaling 14 antibody RGS 14 antibody RGS14 antibody RGS14_HUMAN antibody

Uniprot ID :

O43566

more info or order :

Boster Immunoleader product webpage