Boster Immunoleader

antibody

Anti-Cyclophilin B Antibody

PA2151

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-Cyclophilin B Antibody

PA2151

Polyclonal

Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase B(PPIB) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse; Predicted Species: Rat

WB: The detection limit for PPIB is approximately 1.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Cyclophilin B(176-196aa MEVVRKVESTKTDSRDKPLKD), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Peptidyl-prolyl cis-trans isomerase B, also known as CYPB, is an enzyme that in humans is encoded by the PPIB gene. This gene is mapped to 15q22.31. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.

1. Barnes, A. M., Cabral, W. A., Weis, M., Makareeva, E., Mertz, E. L., Leikin, S., Eyre, D., Trujillo, C., Marini, J. C. Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix. Hum. Mutat. 33: 1589-1598, 2012. 2. van Dijk, F. S., Cobben, J. M., Pals, G. Osteogenesis imperfecta, normal collagen folding, and lack of cyclophilin B. (Letter) New Eng. J. Med. 362: 1940-1941, 2010. 3. Watashi, K., Ishii, N., Hijikata, M., Inoue, D., Murata, T., Miyanari, Y., Shimotohno, K.Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Molec. Cell 19: 111-122, 2005.

PPIB

Peptidyl-prolyl cis-trans isomerase B

peptidylprolyl isomerase B(cyclophilin B)

AA408962 antibody AA553318 antibody AI844835 antibody Cphn 2 antibody Cphn2 antibody Cyclophilin B antibody Cyclophilin like protein antibody CyP 20b antibody CYP S1 antibody CYP-S1 antibody CYPB antibody EC 5.2.1.8 antibody MGC14109 antibody MGC2224 antibody OI9 antibody peptidyl prolyl cis trans isomerase B antibody Peptidyl prolyl cis trans isomerase B precursor antibody Peptidyl-prolyl cis-trans isomerase B antibody Peptidyl-prolyl cis-trans isomerase B precursor antibody peptidylprolyl isomerase B(cyclophilin B) antibody Peptidylprolyl isomerase B antibody PPIase antibody PPIase B antibody PPIB antibody PPIB_HUMAN antibody Rotamase antibody Rotamase B antibody S cyclophilin antibody S-cyclophilin antibody SCYLP antibody

P23284