Boster Immunoleader

antibody

Anti-TrkB Antibody

PA2150

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

info changed 20150417

Anti-TrkB Antibody

PA2150

Polyclonal

Rabbit IgG polyclonal antibody for BDNF/NT-3 growth factors receptor(NTRK2) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: rat Predicted to work with: human, mouse,

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human TrkB(70-90aa EIFIANQKRLEIINEDDVEAY), different from the related mouse and rat sequences by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival.

1. Berghuis, P., Dobszay, M. B., Wang, X., Spano, S., Ledda, F., Sousa, K. M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., Hurd, Y. L., Harkany, T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the NTRK2 receptor. Proc. Nat. Acad. Sci. 102: 19115-19120, 2005. 2. Luberg, K., Wong, J., Weickert, C. S., Timmusk, T. Human NTRK2 gene: novel alterative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. J. Neurochem. 113: 952-964, 2010. 3. Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M., Barde, Y.-A. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas NTRK2 does not. Nature 467: 59-63, 2010.

NTRK2

BDNF/NT-3 growth factors receptor

neurotrophic tyrosine kinase, receptor, type 2

AI848316 antibody BDNF tropomyosine receptor kinase B antibody BDNF/NT 3 growth factors receptor antibody BDNF/NT-3 growth factors receptor antibody Brain derived neurotrophic factor receptor antibody C030027L06Rik antibody EC 2.7.10.1 antibody GP145 TrkB antibody GP145-TrkB antibody GP145-TrkB/GP95-TrkB antibody GP95 TrkB antibody Neurotrophic tyrosine kinase receptor type 2 antibody Neurotrophin receptor tyrosine kinase type 2 antibody NTRK 2 antibody NTRK2 antibody NTRK2_HUMAN antibody Obesity, hyperphagia, and developmental delay, included antibody RATTRKB1 antibody Tkrb antibody Trk B antibody Trk-B antibody TRKB antibody TrkB tyrosine kinase antibody TRKB1 antibody Tropomyosin related kinase B antibody tyrosine kinase receptor B antibody Tyrosine receptor kinase B antibody

Q16620