Anti-FGFR3 Antibody | Boster Immunoleader PA2143 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-FGFR3 Antibody

catalog :

PA2143

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-FGFR3 Antibody

Catalog Number :

PA2143

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Fibroblast growth factor receptor 3(FGFR3) detection. Tested with WB, IHC-P, ICC in Human;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat

Applications :

WB,IHC-P,ICC

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat

Immunocytochemistry :

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human FGFR3(110-129aa RQRLTQRVLCHFSVRVTDAP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P) and ICC.

Background :

Fibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. This gene encodes a member of the fibroblast growth factor receptor(FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. The FGFR3 gene is mapped to the HD region on chromosome 4p16.3. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Reference :

1. Almeida, M. R., Campos-Xavier, A. B., Medeira, A., Cordeiro, I., Sousa, A. B., Lima, M., Soares, G., Rocha, M., Saraiva, J., Ramos, L., Sousa, S., Marcelino, J. P., Correia, A., Santos, H. G. Clinical and molecular diagnosis of the skeletal dysplasias associated with mutations in the gene encoding fibroblast growth factor receptor 3 (FGFR3) in Portugal. Clin. Genet. 75: 150-156, 2009. 2. Barroso, E., Perez-Carrizosa, V., Garcia-Recuero, I., Glucksman, M. J., Wilkie, A. O., Garcia-Minaur, S., Heath, K. E. Mild isolated craniosynostosis due to a novel FGFR3 mutation, p.Ala334Thr. Am. J. Med. Genet. 155A: 3050-3053, 2011.

Gene Name :

FGFR3

Protein Name :

Fibroblast growth factor receptor 3

Gene Full Name :

fibroblast growth factor receptor 3

Synonyms :

ACH antibody CD 333 antibody CD333 antibody CD333 antigen antibody CEK 2 antibody CEK2 antibody FGFR 3 antibody FGFR-3 antibody FGFR3 antibody FGFR3_HUMAN antibody Fibroblast growth factor receptor 3(achondroplasia thanatophoric dwarfism) antibody Fibroblast growth factor receptor 3 antibody Heparin binding growth factor receptor antibody HSFGFR3EX antibody Hydroxyaryl protein kinase antibody JTK 4 antibody JTK4 antibody MFR 3 antibody SAM 3 antibody Tyrosine kinase JTK 4 antibody Tyrosine kinase JTK4 antibody Z FGFR 3 antibody

Uniprot ID :

P22607

more info or order :

Boster Immunoleader product webpage