Boster Immunoleader

antibody

Anti-SMAD6 Antibody

PA2134

100 ug/vial

200 USD

polyclonal

rabbit

Anti-SMAD6 Antibody

PA2134

Polyclonal

Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 6(SMAD6) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for SMAD6 is approximately 1.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human SMAD6(436-452aa IKVFDFERSGLQHAPEP).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Mothers against decapentaplegic homolog 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. It belongs to the SMAD family of proteins, which belongs to the TGFbeta superfamily of modulators. By PCR screening of a somatic cell hybrid panel and YACs, this gene was mapped to 15q22.31. This gene acts as a mediator of TGF-beta and BMP antiflammatory activity. It can suppress 1L 1R-TLR signaling through its direct interaction with PEL1 and prevent NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. SMAD6 may play a role in blocking the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding and binding to regulatory elements in target promoter regions.

1. Galvin, K. M., Donovan, M. J., Lynch, C. A., Meyer, R. I., Paul, R. J., Lorenz, J. N., Fairchild-Huntress, V., Dixon, K. L., Dunmore, J. H., Gimbrone, M. A., Jr., Falb, D., Huszar, D. A role for SMAD6 in development and homeostasis of the cardiovascular system. Nature Genet. 24: 171-174, 2000. 2. Tan, H. L., Glen, E., Topf, A., Hall, D., O'Sullivan, J. J., Sneddon, L., Wren, C., Avery, P., Lewis, R. J., ten Dijke, P., Arthur, H. M., Goodship, J. A., Keavney, B. D.Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Hum. Mutat. 33: 720-727, 2012. 3. Topper, J. N., Cai, J., Qiu, Y., Anderson, K. R., Xu, Y.-Y., Deeds, J. D., Feeley, R., Gimeno, C. J., Woolf, E. A., Tayber, O., Mays, G. G., Sampson, B. A., Schoen, F. J., Gimbrone, M. A., Jr., Falb, D. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Nat. Acad. Sci. 94: 9314-9319, 1997.

SMAD6

Mothers against decapentaplegic homolog 6

SMAD family member 6

hSMAD6 antibody HsT17432 antibody MAD(mothers against decapentaplegic Drosophila) homolog 6 antibody MAD homolog 6 antibody MAD mothers against decapentaplegic homolog 6(Drosophila) antibody MADH6 antibody MADH7 antibody Mothers against decapentaplegic drosophila homolog of 6 antibody Mothers against decapentaplegic homolog 6 antibody Mothers against DPP homolog 6 antibody SMAD 6 antibody SMAD family member 6 antibody SMAD mothers against DPP homolog 6 antibody Smad6 antibody SMAD6_HUMAN antibody

O43541