Boster Immunoleader

antibody

Anti-Parathyroid Hormone Receptor 1 Antibody

PA2132

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunocytochemistry, immunohistochemistry - paraffin section

Anti-Parathyroid Hormone Receptor 1 Antibody

PA2132

Polyclonal

Rabbit IgG polyclonal antibody for Parathyroid hormone/parathyroid hormone-related peptide receptor(PTH1R) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB,IHC-P,ICC

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Parathyroid Hormone Receptor 1(388-406aa KLRETNAGRCDTRQQYRKL), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P) and ICC.

Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as PTH1R, PTHR, is a protein that in humans is encoded by the PTH1R gene. PTHR is a member of a family of G protein-coupled receptors. PTHR gene was mapped to the vicinity of the 3p21.3-p21.2 boundary by PCR analysis of human/rodent somatic cell hybrid panels using oligonucleotide primers designed to amplify a portion of the gene from genomic DNA. This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. PTH1R functions as a receptor for parathyroid hormone and for parathyroid hormone-related protein.

1. Bastepe, M., Raas-Rothschild, A., Silver, J., Weissman, I., Wientroub, S., Juppner, H., Gillis, D. A form of Jansen's metaphyseal chondrodysplasia with limited metabolic and skeletal abnormalities is caused by a novel activating parathyroid hormone (PTH)/PTH-related peptide receptor mutation. J. Clin. Endocr. Metab. 89: 3595-3600, 2004. 2. Decker, E., Stellzig-Eisenhauer, A., Fiebig, B. S., Rau, C., Kress, W., Saar, K., Ruschendorf, F., Hubner, N., Grimm, T., Weber, B. H. F. PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Am. J. Hum. Genet. 83: 781-786, 2008. 3. Hoogendam, J., Farih-Sips, H., Wynaendts, L. C., Lowik, C. W. G. M., Wit, J. M., Karperien, M. Novel mutations in the parathyroid hormone (PTH)/PTH-related peptide receptor type 1 causing Blomstrand osteochondrodysplasia types I and II. J. Clin. Endocr. Metab. 92: 1088-1095, 2007. 4. Wang, B., Yang, Y., Friedman, P. A. Na/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway. Mol. Biol. Cell 19: 1637-1645, 2008.

PTH1R

Parathyroid hormone/parathyroid hormone-related peptide receptor

parathyroid hormone 1 receptor

MGC138426 antibody MGC138452 antibody Parathyroid hormone 1 receptor antibody Parathyroid hormone/parathyroid hormone related peptide receptor antibody Parathyroid hormone/parathyroid hormone related protein receptor antibody Parathyroid hormone/parathyroid hormone-related peptide receptor antibody PTH receptor antibody PTH/PTHr receptor antibody PTH/PTHrP receptor antibody PTH/PTHrP type I receptor antibody PTH1 receptor antibody PTH1R antibody PTH1R_HUMAN antibody PTHR 1 antibody PTHR antibody PTHR1 antibody

Q03431