Boster Immunoleader

antibody

Anti-Cdk7 Antibody

PA2126-2

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-Cdk7 Antibody

PA2126-2

Polyclonal

Rabbit IgG polyclonal antibody for Cyclin-dependent kinase 7(CDK7) detection. Tested with WB in Human;Rat;Mouse.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cdk7(329-346aa RKRAEALEQGILPKKLIF), identical to the related rat sequence, and different from the related human sequence by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Cyclin-dependent kinase 7, also known as cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. The gene was assigned to human chromosome 5q13.2. Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. CDK7 is the catalytic subunit of the CDK-activating kinase(CAK) complex. It is required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

1. Chen, J., Larochelle, S., Li, X., Suter, B. Xpd/Ercc2 regulates CAK activity and mitotic progression. Nature 424: 228-232, 2003. 2. Larochelle, S., Merrick, K. A., Terret, M.-E., Wohlbold, L., Barboza, N. M., Zhang, C., Shokat, K. M., Jallepalli, P. V., Fisher, R. P. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007. 3. Levedakou, E. N., He, M., Baptist, E. W., Craven, R. J., Cance, W. G., Welcsh, P. L., Simmons, A., Naylor, S. L., Leach, R. L., Lewis, T. B., Bowcock, A., Liu, E. T. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9: 1977-1988, 1994. 4. Shiekhattar, R., Mermelstein, F., Fisher, R. P., Drapkin, R., Dynlacht, B., Wessling, H. C., Morgan, D. O., Reinberg. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374: 283-287, 1995.

CDK7

Cyclin-dependent kinase 7

cyclin-dependent kinase 7

39 kDa protein kinase antibody CAK antibody CAK1 antibody Cdk activating kinase antibody CDK-activating kinase 1 antibody CDK-activating kinase antibody cdk7 antibody CDK7_HUMAN antibody CDKN7 antibody Cell division protein kinase 7 antibody Cyclin dependent kinase 7 antibody cyclin-dependent kinase 7(MO15 homolog, Xenopus laevis, cdk-activating kinase) antibody Cyclin-dependent kinase 7 antibody HCAK antibody Homolog of Xenopus MO15 Cdk activating kinase antibody Kinase subunit of CAK antibody MO15 antibody MO15, Xenopus, homolog of antibody P39 Mo15 antibody p39MO15 antibody Serine threonine kinase Stk1 antibody Serine/threonine protein kinase 1 antibody Serine/threonine protein kinase MO15 antibody STK1 antibody TFIIH basal transcription factor complex kinase subunit antibody

Q03147