Anti-RUNX3 Antibody | Boster Immunoleader PA2112 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-RUNX3 Antibody

catalog :

PA2112

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-RUNX3 Antibody

Catalog Number :

PA2112

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Runt-related transcription factor 3(RUNX3) detection. Tested with WB in Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat

Notes :

WB: The detection limit for RUNX3 is approximately 10ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of mouse RUNX3(186-205aa QKIEDQTKAFPDRFGDLRMR), identical to the related rat sequence.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Runt-related transcription factor 3, also called AML2 is a protein that in humans is encoded by the RUNX3 gene. The RUNX3 gene encodes a Runt-related transcription factor, which is part of the RUNX gene family. By fluorescence in situ hybridization, RUNX3 was assigned to human chromosome 1p36.11. RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. It may be involved in the control of cellular proliferation and/or differentiation.

Reference :

1. Brenner, O., Levanon, D., Negreanu, V., Golubkov, O., Fainaru, O., Woolf, E., Groner, Y. Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc. Nat. Acad. Sci. 101: 16016-16021, 2004. 2. Fainaru, O., Shseyov, D., Hantisteanu, S., Groner, Y. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc. Nat. Acad. Sci. 102: 10598-10603, 2005. 3. Ito, K., Liu, Q., Salto-Tellez, M., Yano, T., Tada, K., Ida, H., Huang, C., Shah, N., Inoue, M., Rajnakova, A., Hiong, K. C., Peh, B. K., Han, H. C., Ito, T., Teh, M., Yeoh, K. G., Ito, Y. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res. 65: 7743-7750, 2005. 4. Li, Q.-L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.-Z., Lee, K.-Y., Nomura, S., Lee, C.-W., Han, S.-B., Kim, H.-M., Kim, W.-J., and 15 others. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109: 113-124, 2002.

Gene Name :

RUNX3

Protein Name :

Runt-related transcription factor 3

Gene Full Name :

runt-related transcription factor 3

Synonyms :

Acute myeloid leukemia 2 protein antibody Acute myeloid leukemia gene 2 antibody AML 2 antibody AML2 antibody CBF alpha 3 antibody CBF-alpha-3 antibody CBFA 3 antibody CBFA3 antibody Core binding factor alpha 3 subunit antibody core binding factor antibody Core binding factor runt domain alpha subunit 3 antibody Core binding factor subunit alpha 3 antibody core-binding factor antibody Core-binding factor subunit alpha-3 antibody FLJ34510 antibody MGC16070 antibody Oncogene AML 2 antibody Oncogene AML-2 antibody PEA2 alpha C antibody PEA2-alpha C antibody PEBP2 alpha C antibody PEBP2-alpha C antibody Pebp2a3 antibody PEBP2aC antibody Polyomavirus enhancer binding protein 2 alpha C subunit antibody Polyomavirus enhancer-binding protein 2 alpha C subunit antibody runt domain alpha subunit 3 antibody runt related transcription factor 3 antibody Runt-related transcription factor 3 antibody RUNX 3 antibody Runx3 antibody RUNX3_HUMAN antibody SL3 3 enhancer factor 1 alpha C subunit antibody SL3-3 enhancer factor 1 alpha C subunit antibody SL3/AKV core binding factor alpha C subunit antibody SL3/AKV core-binding factor alpha C subunit antibody Transcription factor AML2 antibody

Uniprot ID :

Q64131

more info or order :

Boster Immunoleader product webpage