Boster Immunoleader

antibody

Anti-NFkB p105/p50 Antibody

PA2111-1

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-NFkB p105/p50 Antibody

PA2111-1

Polyclonal

Rabbit IgG polyclonal antibody for Nuclear factor NF-kappa-B p105 subunit(NFKB1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human NFkB p105(193-208aa KELIRQAALQQTKEMD), different from the related rat sequence by one amino acid and from the related mouse sequence by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Nuclear factor NF-kappa-B p105 subunit, also called EBP-1 is a protein that in humans is encoded by the NFKB1 gene. By fluorescence in situ hybridization, the gene was assigned to human chromosome 4q24. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing.

1. Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., Chang, H. Y. Motif module map reveals enforcement of aging by continual NF-kappa-beta activity. Genes Dev. 21: 3244-3257, 2007. 2. Baek, S. H., Ohgi, K. A., Rose, D. W., Koo, E. H., Glass, C. K., Rosenfeld, M. G. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappa-B and beta-amyloid precursor protein. Cell 110: 55-67, 2002. 3. Huxford, T., Huang, D.-B., Malex, S., Ghosh, G. The crystal structure of the I-kappa-B-alpha complex reveals mechanisms of NF-kappa-B inactivation. Cell 95: 759-770, 1998.

NFKB1

Nuclear factor NF-kappa-B p105 subunit

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

DKFZp686C01211 antibody DNA binding factor KBF1 antibody DNA binding factor KBF1 EBP1 antibody DNA-binding factor KBF1 antibody EBP 1 antibody EBP-1 antibody EBP1 antibody KBF1 antibody MGC54151 antibody NF kappa B antibody NF kappabeta antibody NF kB1 antibody NFKB 1 antibody NFKB p105 antibody NFKB p50 antibody Nfkb1 antibody NFKB1_HUMAN antibody Nuclear factor kappa B DNA binding subunit antibody Nuclear factor NF kappa B p105 subunit antibody Nuclear factor NF kappa B p50 subunit antibody Nuclear factor NF-kappa-B p50 subunit antibody Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 antibody Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antibody p84/NF-kappa-B1 p98 antibody

P19838