Anti-Ataxin 1 Antibody | Boster Immunoleader PA2097 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Ataxin 1 Antibody

catalog :

PA2097

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Ataxin 1 Antibody

Catalog Number :

PA2097

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Ataxin-1(ATXN1) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for ATXN1 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human Ataxin 1(390-405aa TPAADLEVQQATHREA), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Ataxin-1 is a protein that in humans is encoded by the ATXN1 gene. The ATXN1 gene had been mapped to 6p23 by in situ hybridization. Ataxin-1(ATXN1), a causative factor for spinocerebellar ataxia type 1(SCA1), and the related Brother of ATXN1(BOAT1) are human proteins involved in transcriptional repression. ATXN1 and BOAT1 might participate in several Notch-controlled developmental and pathological processes.

Reference :

1. Tong, X., Gui, H., Jin, F., Heck, B. W., Lin, P., Ma, J., Fondell, J. D., Tsai, C.-C. Ataxin-1 and brother of ataxin-1 are components of the Notch signalling pathway. EMBO Rep. 12: 428-435, 2011. 2. Volz A, Fonatsch C, Ziegler A (Jun 1992). "Regional mapping of the gene for autosomal dominant spinocerebellar ataxia (SCA1) by localizing the closely linked D6S89 locus to 6p24.2----p23.05". Cytogenet Cell Genet 60 (1): 37–9. 3. "Entrez Gene: ATXN1 ataxin 1" 4. Volz, A., Boyle, J. M., Cann, H. M., Cottingham, R. W., Orr, H. T., Ziegler, A. Report of the second international workshop on human chromosome 6. Genomics 21: 464, 1994.

Gene Name :

ATXN1

Protein Name :

Ataxin-1

Gene Full Name :

ataxin 1

Synonyms :

Ataxin-1 antibody ATX1 antibody ATX1_HUMAN antibody Atxn1 antibody D6S504E antibody OTTHUMP00000016065 antibody SCA1 antibody Spinocerebellar ataxia type 1 protein antibody

Uniprot ID :

P54253

more info or order :

Boster Immunoleader product webpage