Boster Immunoleader

antibody

Anti-Aquaporin 7 Antibody

PA2093

100 ug/vial

200 USD

polyclonal

rabbit

Anti-Aquaporin 7 Antibody

PA2093

Polyclonal

Rabbit IgG polyclonal antibody for Aquaporin-7(AQP7) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for AQP7 is approximately 1.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human Aquaporin 7(23-42aa AKIQEILQRKMVREFLAEFM).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Aquaporin-7 is a protein that in humans is encoded by the AQP7 gene. The human AQP7 gene is composed of six exons distributing over 6.5 kb. The exon-intron boundaries are identical to those of the human AQP3 gene. The intron sizes are also similar. Moreover, chromosomal localization of AQP7 was assigned to 9p13 by fluorescent in situ hybridization, where AQP3 is also localized, suggesting that 9p13 may be another site of an aquaporin cluster. AQP7 acts as a glycerol facilitator in cardiomyocytes and that glycerol is a substrate for cardiac energy production. AQP7 is down-regulated in women with severe obesity. The expression of this glycerol channel is not affected by type 2 diabetes.

1. Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem272 (33): 20782–6. 2. "Entrez Gene: AQP7 aquaporin 7" 3. Ishibashi, K., Yamauchi, K., Kageyama, Y., Saito-Ohara, F., Ikeuchi, T., Marumo, F., Sasaki, S. Molecular characterization of human aquaporin-7 gene and its chromosomal mapping. Biochim. Biophys. Acta 1399: 62-66, 1998. 4. Hibuse, T., Maeda, N., Nakatsuji, H., Tochino, Y., Fujita, K., Kihara, S., Funahashi, T., Shimomura, I. The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator. Cardiovasc. Res. 83: 34-41, 2009. 5. Ceperuelo-Mallafre, V., Miranda, M., Chacon, M. R., Vilarrasa, N., Megia, A., Gutierrez, C., Fernandez-Real, J. M., Gomez, J. M., Caubet, E., Fruhbeck, G., Vendrell, J. Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. J. Clin. Endocr. Metab. 92: 3640-3645, 2007.

AQP7

Aquaporin-7

aquaporin 7

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O14520