Boster Immunoleader

antibody

Anti-CXCR4 Antibody

PA2081

100 ug/vial

200 USD

polyclonal

rabbit

Anti-CXCR4 Antibody

PA2081

Polyclonal

Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 4(CXCR4) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4(31-43aa EENANFNKIFLPT).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

CXCR4(Chemokine,CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. By PCR analysis of human/hamster hybrid cell DNA, Herzog et al.(1993) showed that the NPY3R gene is located on human chromosome 2. Feng et al.(1996) showed that transient expression of the CXCR4 gene allowed nonhuman cells coexpressing recombinant CD4 to undergo Env-CD4-mediated cell fusion and productive HIV-1 infection. Peled et al.(1999) demonstrated that SDF1 and its receptor CXCR4 are critical for murine bone marrow engraftment by human SCID repopulating stem cells. Treatment of human cells with anti-CXCR antibodies prevented engraftment.

1. Feng, Y., Broder, C. C., Kennedy, P. E., Berger, E. A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872-876, 1996. 2. Herzog, H., Hort, Y. J., Shine, J., Selbie, L. A. Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA Cell Biol. 12: 465-471, 1993. 3. Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., Lider, O., Alon, R., Zipori, D., Lapidot, T. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283: 845-848, 1999.

CXCR4

C-X-C chemokine receptor type 4

chemokine(C-X-C motif) receptor 4

C-X-C chemokine receptor type 4 antibody CD184 antibody CD184 antigen antibody Chemokine(C X C motif) receptor 4 antibody Chemokine CXC Motif Receptor 4 antibody CXC-R4 antibody CXCR-4 antibody CXCR4 antibody CXCR4_HUMAN antibody D2S201E antibody FB22 antibody Fusin antibody HM89 antibody HSY3RR antibody LAP 3 antibody LAP3 antibody LCR1 antibody LESTR antibody Leukocyte derived seven transmembrane domain receptor antibody Leukocyte-derived seven transmembrane domain receptor antibody Lipopolysaccharide associated protein 3 antibody Neuropeptide Y receptor Y3 antibody NPY3R antibody NPYR antibody NPYRL antibody NPYY3 antibody NPYY3R antibody Probable G protein coupled receptor lcr1 homolog antibody SDF 1 receptor antibody SDF-1 receptor antibody SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR antibody Stromal cell derived factor 1 receptor antibody Stromal cell-derived factor 1 receptor antibody WHIM antibody

P61073