Anti-CXCR1 Antibody | Boster Immunoleader PA2080 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CXCR1 Antibody

catalog :

PA2080

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section

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product information

Product Name :

Anti-CXCR1 Antibody

Catalog Number :

PA2080

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1(24-38aa DEDYSPCMLETETLN).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

CXCR1(Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al.(1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA(GRO) with a low affinity.

Reference :

1. Hartl, D., Latzin, P., Hordijk, P., Marcos, V., Rudolph, C., Woischnik, M., Krauss-Etschmann, S., Koller, B., Reinhardt, D., Roscher, A. A., Roos, D., Griese, M. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nature Med. 13: 1423-1430, 2007. 2. Morris, S. W., Nelson, N., Valentine, M. B., Shapiro, D. N., Look, A. T., Kozlosky, C. J., Beckmann, M. P., Cerretti, D. P. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. Genomics 14: 685-691, 1992. 3. Vasilescu, A., Terashima, Y., Enomoto, M., Heath, S., Poonpiriya, V., Gatanaga, H., Do, H., Diop, G., Hirtzig, T., Auewarakul, P., Lauhakirti, D., Sura, T., Charneau, P., Marullo, S., Therwath, A., Oka, S., Kanegasaki, S., Lathrop, M., Matsushima, K., Zagury, J.-F., Matsuda, F. A haplotype of the human CXCR1 gene protective against rapid disease progression in HIV-1+ patients. Proc. Nat. Acad. Sci. 104: 3354-3359, 2007.

Gene Name :

CXCR1

Protein Name :

C-X-C chemokine receptor type 1

Gene Full Name :

chemokine(C-X-C motif) receptor 1

Synonyms :

C C antibody C C CKR 1 antibody C-X-C chemokine receptor type 1 antibody CCCKR1 antibody CD 181 antibody CD128 antibody CD181 antibody CD181 antigen antibody CDw128a antibody Chemokine(C X C motif) receptor 1 antibody Chemokine(C X C) receptor 1 antibody Chemokine receptor 1 antibody CKR 1 antibody CMKAR1 antibody CXC-R1 antibody CXCR 1 antibody CXCR-1 antibody CXCR1 antibody CXCR1_HUMAN antibody High affinity interleukin 8 receptor A antibody High affinity interleukin-8 receptor A antibody IL 8 receptor type 1 antibody IL 8R A antibody IL-8 receptor type 1 antibody IL-8R A antibody IL8 receptor antibody IL8 receptor type 1 antibody IL8R1 antibody IL8RA antibody IL8RBA antibody Interleukin 8 receptor alpha antibody Interleukin 8 receptor type 1 antibody Interleukin 8 receptor type A antibody

Uniprot ID :

P25024

more info or order :

Boster Immunoleader product webpage