Anti-ABCA4 Antibody | Boster Immunoleader PA2065 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-ABCA4 Antibody

catalog :

PA2065

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-ABCA4 Antibody

Catalog Number :

PA2065

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Retinal-specific ATP-binding cassette transporter(ABCA4) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human ABCA4(1893-1906aa TLLVQRHFFLSQWI).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

ABCA4(ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A(ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, Allikmets et al.(1997) mapped the ABCR gene to 1p21-p13. Allikmets et al.(1997) localized ABCR transcripts exclusively within photoreceptor cells, indicating that ABCR mediates the transport of an essential molecule(or ion) either into or out of photoreceptor cells. Molday et al.(2000) showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.

Reference :

1. Allikmets, R., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A., Zabriskie, N. A., Hutchinson, A., Dean, M., Lupski, J. R., Leppert, M. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277: 1805-1807, 1997. 2. Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., Rattner, A., Smallwood, P., Li, Y., Anderson, K. L., Lewis, R. A., Nathans, J., Leppert, M., Dean, M., Lupski, J. R. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nature Genet. 15: 236-246, 1997. Note: Erratum: Nature Genet. 17:122 only, 1997. 3. Molday, L. L., Rabin, A. R., Molday, R. S. ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy. Nature Genet. 25: 257-258, 2000.

Gene Name :

ABCA4

Protein Name :

Retinal-specific ATP-binding cassette transporter

Gene Full Name :

ATP-binding cassette, sub-family A(ABC1), member 4

Synonyms :

ABC 10 antibody ABC A4 antibody ABC10 antibody ABCA 4 antibody abcA4 antibody ABCA4_HUMAN antibody ABCR antibody ARMD 2 antibody ARMD2 antibody ATP binding cassette 10 antibody ATP binding cassette sub family A member 4 antibody ATP binding cassette sub family A member4 antibody ATP binding cassette transporter antibody ATP binding cassette transporter retinal specific antibody ATP binding cassette, sub family A(ABC1), member 4 antibody ATP binding cassette, sub family A(ABC1), member4 antibody ATP binding cassette10 antibody ATP binding transporter, retina specific antibody ATP-binding cassette sub-family A member 4 antibody CORD 3 antibody CORD3 antibody DKFZp781N1972 antibody FFM antibody FLJ17534 antibody Photoreceptor rim protein antibody Retina specific ABC transporter antibody Retinal specific ATP binding cassette transporter antibody Retinal-specific ATP-binding cassette transporter antibody RIM ABC transporter antibody RIM protein antibody RmP antibody RP 19 antibody RP19 antibody Stargardt disease protein antibody STGD antibody STGD1 antibody

Uniprot ID :

P78363

more info or order :

Boster Immunoleader product webpage