Anti-Prothrombin Antibody | Boster Immunoleader PA2058 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Prothrombin Antibody

catalog :

PA2058

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Prothrombin Antibody

Catalog Number :

PA2058

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Prothrombin(F2) detection. Tested with WB in Human;Mouse.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human Prothrombin(608-619aa RLKKWIQKVIDQ), different from the related mouse sequence by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

F2(Coagulation Factor II), also known as thrombin, is a serine protease that in humans is encoded by the F2 gene. Royle et al.(1987) assigned the gene for human prothrombin(F2) to chromosome 11p11-q12 by analysis of a panel of somatic cell hybrid DNAs and by in situ hybridization, using both cDNA and genomic probes. The activated thrombin enzyme plays an important role in hemostasis and thrombosis: it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII(F8), and XIII(F13A1). Thrombin also inhibits coagulation by activating protein C.

Reference :

1. Lancellotti, S., De Cristofaro, R. Congenital prothrombin deficiency. Semin. Thromb. Hemost. 35: 367-381, 2009. 2. Royle, N. J., Irwin, D. M., Koschinsky, M. L., MacGillivray, R. T. A., Hamerton, J. L. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Molec. Genet. 13: 285-292, 1987.

Gene Name :

Protein Name :

Prothrombin

Gene Full Name :

coagulation factor II(thrombin)

Synonyms :

coagulation factor II(thrombin) antibody Coagulation factor II antibody Coagulation factor II precursor antibody Coagulation factor II thrombin antibody Dysprothrombinemia antibody EC 3.4.21.5 antibody F 2 antibody F2 antibody Factor II antibody Hyperprothrombinemia antibody Hypoprothrombinemia antibody Prepro coagulation factor II antibody Prothrombin antibody Prothrombin B chain antibody prothrombin B-chain antibody PT antibody RPRGL2 antibody Serine protease antibody THPH1 antibody THRB antibody THRB_HUMAN antibody Thrombin antibody Thrombin heavy chain antibody

Uniprot ID :

P00734

more info or order :

Boster Immunoleader product webpage