Boster Immunoleader

antibody

Anti-PER1 Antibody

PA2044

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-PER1 Antibody

PA2044

Polyclonal

Rabbit IgG polyclonal antibody for Period circadian protein homolog 1(PER1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

WB: The detection limit for PER1 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human PER1(289-302aa RDFTQEKSVFCRIR), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

PER1(Period, Drosophila, Homolog of), also known as PER or RIGUI, is a protein that in humans is encoded by the PER1 gene. By fluorescence in situ hybridization, Sun et al.(1997) mapped the human PER1 gene to 17p12. Sun et al.(1997) found that in mouse retina, the expression of rigui oscillated over a 24-hour period, with highest expression at onset of dark in a 12-hour light/dark cycle, i.e., expression rose during the light period and fell during the dark period. RNA abundance of rigui changed 2.9-fold between highest and lowest levels in mouse retina. Shigeyoshi et al.(1997) examined the effects of light on rigui, designated mouse Per1 by them, which exhibits robust rhythmic expression in the SCN. They found that Per1 is rapidly induced by short duration exposure to light at levels sufficient to reset the clock. Von Gall et al.(2002) demonstrated that cycling expression of the clock gene Per1 in rodent pituitary cells depends on the heterologous sensitization of the adenosine A2B receptor, which occurs through the nocturnal activation of melatonin mt1 receptors.

1. Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., Okamura, H. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 91: 1043-1053, 1997. 2. Sun, Z. S., Albrecht, U., Zhuchenko, O., Bailey, J., Eichele, G., Lee, C. C. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 90: 1003-1011, 1997. 3. von Gall, C., Garabette, M. L., Kell, C. A., Frenzel, S., Dehghani, F., Schumm-Draeger, P.-M., Weaver, D. R., Korf, H.-W., Hastings, M. H., Stehle, J. H. Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin. Nature Neurosci. 5: 234-238, 2002.

PER1

Period circadian protein homolog 1

period circadian clock 1

Circadian clock protein PERIOD 1 antibody Circadian clock protein PERIOD1 antibody Circadian pacemaker protein Rigui antibody hPER 1 antibody hPER antibody hPER1 antibody KIAA0482 antibody MGC88021 antibody PER 1 antibody PER antibody PER1 antibody PER1 protein antibody PER1_HUMAN antibody Period 1 antibody Period circadian protein homolog 1 antibody Period drosophila homolog of antibody Period homolog 1 antibody Period1 antibody RIGUI antibody

O15534