Boster Immunoleader

antibody

Anti-NTAL Antibody

PA2039

100 ug/vial

200 USD

polyclonal

rabbit

Anti-NTAL Antibody

PA2039

Polyclonal

Rabbit IgG polyclonal antibody for Linker for activation of T-cells family member 2(LAT2) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for LAT2 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human NTAL(34-48aa KRSEKIYQQRSLRED).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

LAT2(Linker for Activation of T Cells Family, Member 2), also known as LAB or NTAL , is a protein that in humans is encoded by the LAT2 gene. By genomic sequence analysis, Doyle et al.(2000) mapped the WBSCR5 gene to chromosome 7q11.23. They noted that the flanking genes are highly conserved between mouse and human. By immunoprecipitation and immunoblot analysis, Brdicka et al.(2002) found that NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Janssen et al.(2003) determined that phosphorylation of LAB is likely mediated by SYK upon B-cell receptor stimulation. Binding analysis indicated associations with GRB2, and, indirectly, with PLCG1 and PLCG2.

1. Brdicka, T., Imrich, M., Angelisova, P., Brdickova, N., Horvath, O., Spicka, J., Hilgert, I., Luskova, P., Draber, P., Novak, P., Engels, N., Wienands, J., Simeoni, L., Osterreicher, J., Aguado, E., Malissen, M., Schraven, B., Horejsi, V. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 1617-1626, 2002. 2. Doyle, J. L., DeSilva, U., Miller, W., Green, E. D. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet. Cell Genet. 90: 285-290, 2000. 3. Janssen, E., Zhu, M., Zhang, W., Koonpaew, S., Zhang, W. LAB: a new membrane-associated adaptor molecule in B cell activation. Nature Immun. 4: 117-123, 2003.

LAT2

Linker for activation of T-cells family member 2

linker for activation of T cells family, member 2

HSPC046 antibody LAB antibody Lat2 antibody Linker for activation of B cells antibody Linker for activation of B-cells antibody Linker for activation of T cells family member 2 antibody Linker for activation of T cells transmembrane adaptor 2 antibody Linker for activation of T-cells family member 2 antibody Linker of Activated B cells antibody Membrane associated adapter molecule antibody Membrane-associated adapter molecule antibody Non T Cell Activation Linker antibody Non-T-cell activation linker antibody NTAL_HUMAN antibody WBSCR 5 antibody Wbscr15 antibody Williams Beuren syndrome chromosome region 15 antibody Williams Beuren Syndrome chromosome region 5 antibody Williams-Beuren syndrome chromosomal region 15 protein antibody Williams-Beuren syndrome chromosomal region 5 protein antibody WSCR5 antibody

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