Boster Immunoleader

antibody

Anti-EPO Receptor Antibody

PA2032

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse

Anti-EPO Receptor Antibody

PA2032

Polyclonal

Rabbit IgG polyclonal antibody for Erythropoietin receptor(EPOR) detection. Tested with WB in Human;Mouse.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse

WB: The detection limit for EPOR is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human EPO Receptor(362-379aa EHAQDTYLVLDKWLLPRN), identical to the related mouse sequence, and different from the related rat sequence by three amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

EPOR(Erythropoietin Receptor), is a protein that in humans is encoded by the EPOR gene. Jones et al.(1990) isolated the human homolog of the murine erythropoietin receptor(EPOR) from an erythroleukemia cell line and from fetal liver. Budarf et al.(1990) mapped the EPOR gene to human 19pter-q12 by somatic cell hybrid analysis. Akashi et al.(2000) reported the prospective identification, purification, and characterization, using cell surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloid lineages. The distinction between the common lymphoid progenitor and common myeloid progenitor is that the common lymphoid progenitor expresses IL7 receptor and does not express MPL, whereas the common myeloid progenitor does not express the IL7 receptor and expresses MPL. Becker et al.(2010) showed by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the EPO receptor.

1. Akashi, K., Traver, D., Miyamoto, T., Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197, 2000. 2. Becker, V., Schilling, M., Bachmann, J., Baumann, U., Raue, A., Maiwald, T., Timmer, J., Klingmuller, U. Covering a broad dynamic range: information processing at the erythropoietin receptor. Science 328: 1404-1408, 2010. 3. Budarf, M., Huebner, K., Emanuel, B., Croce, C. M., Copeland, N. G., Jenkins, N. A., D'Andrea, A. D. Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19. Genomics 8: 575-578, 1990. 4. Jones, S. S., D'Andrea, A. D., Haines, L. L., Wong, G. G. Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood 76: 31-35, 1990.

EPOR

Erythropoietin receptor

erythropoietin receptor

EPO R antibody EPO-R antibody epor antibody EPOR_HUMAN antibody Erythropoietin receptor antibody Erythropoietin receptor precursor antibody MGC138358 antibody

P19235