Boster Immunoleader

antibody

Anti-VEGF Receptor 2 Antibody

PA1989

100 ug/vial

200 USD

polyclonal

rabbit

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

Anti-VEGF Receptor 2 Antibody

PA1989

Polyclonal

Rabbit IgG polyclonal antibody for Vascular endothelial growth factor receptor 2(KDR) detection. Tested with WB, IHC-P, IHC-F, ICC in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB,IHC-P,IHC-F,ICC

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

WB: The detection limit for KDR is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human VEGF Receptor 2(454-469aa HHIHWYWQLEEECANE).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P), IHC(F) and ICC.

KDR(Kinase Insert Domain Receptor), also known as FLK1, VEGFR or VEGFR2, is a VEGF receptor. KDR is the human gene encoding it. Sait et al.(1995) likewise corrected the assignment to chromosome 4q11-q12 to the same region occupied also by PDGFRA and KIT, thus indicating the location of a cluster of receptor tyrosine kinase genes. Vascular endothelial growth factor(VEGF) is the only mitogen that specifically acts on endothelial cells. Its expression is upregulated by hypoxia, and its cell-surface receptor, known as fetal liver kinase-1(Flk1) in mouse, is exclusively expressed in endothelial cells(Plate et al., 1993). Flk1 is the mouse homolog of KDR(Matthews et al., 1991).

1. Matthews, W., Jordan, C. T., Gavin, M., Jenkins, N. A., Copeland, N. G., Lemischka, I. R. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc. Nat. Acad. Sci. 88: 9026-9030, 1991. 2. Plate, K. H., Breier, G., Millauer, B., Ullrich, A., Risau, W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 53: 5822-5827, 1993. 3. Sait, S. N. J., Dougher-Vermazen, M., Shows, T. B., Terman, B. I. The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11-q12. Cytogenet. Cell Genet. 70: 145-146, 1995.

KDR

Vascular endothelial growth factor receptor 2

kinase insert domain receptor(a type III receptor tyrosine kinase)

CD309 antibody CD309 antigen antibody Fetal liver kinase 1 antibody FLK-1 antibody FLK1 antibody Kdr antibody Kinase insert domain receptor(a type III receptor tyrosine kinase) antibody Kinase insert domain receptor antibody KRD1 antibody Ly73 antibody Protein tyrosine kinase receptor FLK1 antibody Protein-tyrosine kinase receptor flk-1 antibody Tyrosine kinase growth factor receptor antibody Vascular endothelial growth factor receptor 2 antibody VEGFR 2 antibody VEGFR antibody VEGFR-2 antibody VEGFR2 antibody VGFR2_HUMAN antibody

P35968