Anti-TRPV4 Antibody | Boster Immunoleader PA1979 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TRPV4 Antibody

catalog :

PA1979

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-TRPV4 Antibody

Catalog Number :

PA1979

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Transient receptor potential cation channel subfamily V member 4(TRPV4) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human Predicted to work with: mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Notes :

WB: The detection limit for TRPV4 is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human TRPV4(113-133aa YRHHSSDNKRWRKKIIEKQPQ), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

TRPV4(Transient Receptor Potential Cation Channel Subfamily V Member 4), also known as TRP12, OTRPC4 or VROAC, is a protein that in humans is encoded by the TRPV4 gene. This gene encodes TRPV4, a member of the OSM9-like transient receptor potential channel(OTRPC) subfamily in the transient receptor potential(TRP) superfamily of ion channels. By genomic sequence analysis, Liedtke et al.(2000) mapped the TRPV4 gene to chromosome 12q24.1. They mapped the mouse Trpv4 gene to distal chromosome 5 by radiation hybrid analysis. Wissenbach et al.(2000) found that hypoosmotic conditions rapidly activated TRP12, while hyperosmotic conditions inhibited the activity.Strotmann et al.(2000) showed that OTRPC4 was responsive to changes in extracellular osmolarity in the physiologically relevant range and was expressed in tissues exposed to changing osmotic environments.

Reference :

1. Liedtke, W., Choe, Y., Marti-Renom, M. A., Bell, A. M., Denis, C. S., Sali, A., Hudspeth, A. J., Friedman, J. M., Heller, S. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103: 525-535, 2000. 2. Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G., Plant, T. D. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nature Cell. Biol. 2: 695-702, 2000. 3. Wissenbach, U., Bodding, M., Freichel, M., Flockerzi, V. Trp12, a novel Trp related protein from kidney FEBS Lett. 485: 127-134, 2000.

Gene Name :

TRPV4

Protein Name :

Transient receptor potential cation channel subfamily V member 4

Gene Full Name :

transient receptor potential cation channel, subfamily V, member 4

Synonyms :

osm-9-like TRP channel 4 antibody OTRPC 4 antibody OTRPC4 antibody Transient receptor potential cation channel subfamily V member 4 antibody Transient receptor potential protein 12 antibody TRP 12 antibody TRP12 antibody TRPV 4 antibody Vanilloid receptor-like channel 2 antibody Vanilloid receptor-like protein 2 antibody Vanilloid receptor-related osmotically-activated channel antibody VR 4 antibody VR OAC antibody VR4 antibody VRL 2 antibody VRL2 antibody VROAC antibody

Uniprot ID :

Q9HBA0

more info or order :

Boster Immunoleader product webpage