Anti-DR4 Antibody | Boster Immunoleader PA1975 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-DR4 Antibody

catalog :

PA1975

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-DR4 Antibody

Catalog Number :

PA1975

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10A(TNFRSF10A) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for TNFRSF10A is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human DR4(110-125aa TIKLHDQSIGTQQWEH).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

TNFRSF10A(Tumor Necrosis Factor Receptor Subfamily Member 10A), also known as APO2, DR4 or TRAILR1, is a protein that in humans is encoded by the TNFRSF10A gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. By analysis of radiation hybrids, Marsters et al.(1997) mapped the DR4 gene to 8p21. The TRAIL receptor DR5, and 2 decoy receptors for TRAIL, DCR1, and DCR2, are located in the same region, suggesting that these receptors arose from recent gene duplication events. Pan et al.(1997) found that, as with FAS, TNFR1, and DR3, overexpression of DR4 induced apoptosis. However, unlike the other 3 death receptors, DR4 did not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery.

Reference :

1. Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., Ashkenazi, A. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 7: 1003-1006, 1997. 2. Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., Dixit, V. M. The receptor for the cytotoxic ligand TRAIL. Science 276: 111-113, 1997.

Gene Name :

TNFRSF10A

Protein Name :

Tumor necrosis factor receptor superfamily member 10A

Gene Full Name :

tumor necrosis factor receptor superfamily, member 10a

Synonyms :

Apo 2 antibody Apo2 antibody CD 261 antibody CD261 antibody CD261 antigen antibody Cytotoxic ligand TRAIL receptor antibody Cytotoxic TRAIL receptor antibody Death receptor 4 antibody DR 4 antibody DR4 antibody MGC9365 antibody NF related apoptosis-inducing ligand receptor 1 antibody T10A antibody TNF related apoptosis inducing ligand receptor 1 antibody TNF-related apoptosis-inducing ligand receptor 1 antibody TNFRSF10A antibody TR10A_HUMAN antibody TRAIL R1 antibody TRAIL receptor 1 antibody TRAIL-R1 antibody TRAILR 1 antibody TRAILR1 antibody Tumor necrosis factor receptor superfamily member 10a antibody Tumor necrosis factor receptor superfamily member 10A precursor antibody

Uniprot ID :

O00220

more info or order :

Boster Immunoleader product webpage