Anti-NRG1 Antibody | Boster Immunoleader PA1969 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-NRG1 Antibody

catalog :

PA1969

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

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product information

Availability :

info changed 20150325

Product Name :

Anti-NRG1 Antibody

Catalog Number :

PA1969

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Pro-neuregulin-1, membrane-bound isoform(NRG1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

WB,IHC-P,IHC-F,ICC

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Immunohistochemistry(Frozen Section) :

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Immunocytochemistry :

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human NRG1(617-636aa RFSTQEEIQARLSSVIANQD), different from the related rat and mouse sequences by one amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P), IHC(F) and ICC.

Background :

NRG1(Neuregulin 1), also known as ARIA, NDF or HRGA, is a protein that in humans is encoded by the NRG1 gene. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. By in situ hybridization of a tritium-labeled probe to human metaphase spreads, Orr-Urtreger et al.(1993) localized the NDF gene to 8p21-p12. In mouse embryos 14.5 days postcoitum, Orr-Urtreger et al.(1993) found that NDF expression is confined predominantly to the central and peripheral nervous systems, including the neuroepithelium that lines the lateral ventricles of the brain, the ventral horn of the spinal cord, and the intestinal as well as dorsal root ganglia.

Reference :

1. Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Lujan, R., Lloyd, K., Lerma, J., Marin, O., Rico, B. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464: 1376-1380, 2010. 2. Orr-Urtreger, A., Trakhtenbrot, L., Ben-Levy, R., Wen, D., Rechavi, G., Lonai, P., Yarden, Y. Neural expression and chromosomal mapping of NEU differentiation factor to 8p12-p21. Proc. Nat. Acad. Sci. 90: 1867-1871, 1993. 3. Steinthorsdottir, V., Stefansson, H., Ghosh, S., Birgisdottir, B., Bjornsdottir, S., Fasquel, A. C., Olafsson, O., Stefansson, K., Gulcher, J. R. Multiple novel transcription initiation sites for NRG1. Gene 342: 97-105, 2004.

Gene Name :

NRG1

Protein Name :

Pro-neuregulin-1, membrane-bound isoform

Gene Full Name :

neuregulin 1

Synonyms :

Acetylcholine receptor inducing activity antibody Acetylcholine receptor-inducing activity antibody ARIA antibody Breast cancer cell differentiation factor p45 antibody GGF antibody GGF2 antibody Glial growth factor antibody heregulin antibody heregulin, alpha(45kD, ERBB2 p185-activator) antibody HGL antibody HRG antibody HRG1 antibody HRGA antibody MST131 antibody NDF antibody Neu differentiation factor antibody Neuregulin 1 antibody neuregulin 1 type IV beta 1a antibody neuregulin 1 type IV beta 3 antibody Neuregulin-1 antibody NRG 1 antibody nrg1 antibody NRG1_HUMAN antibody OTTHUMP00000225398 antibody OTTHUMP00000225419 antibody OTTHUMP00000225420 antibody OTTHUMP00000225421 antibody OTTHUMP00000225422 antibody OTTHUMP00000225477 antibody OTTHUMP00000225545 antibody OTTHUMP00000230603 antibody OTTHUMP00000230605 antibody Pro-NRG1 antibody ProNRG1 antibody Sensory and motor neuron-derived factor antibody SMDF antibody

Uniprot ID :

Q02297

more info or order :

Boster Immunoleader product webpage