Boster Immunoleader

antibody

Anti-ASIC3 Antibody

PA1938

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

info changed 20150325

Anti-ASIC3 Antibody

PA1938

Polyclonal

Rabbit IgG polyclonal antibody for Acid-sensing ion channel 3(ASIC3) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human ASIC3(56-73aa FLYQVAERVRYYREFHHQ), different from the related rat and mouse sequences by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

ASIC3(Acid-Sensing Ion Channel3), also known as TESTIS SODIUM CHANNEL 1(TNAC1) or DORSAL ROOT ACID-SENSING ION CHANNEL(DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al.(1998) mapped the ACCN3 gene to chromosome 7q35. De Weille et al.(1998) found that human ASIC3 supported an H(+)-gated cation current in COS cells with kinetics similar to those of rat Asic3. Babinski et al.(1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH.

1. Babinski, K., Le, K.-T., Seguela, P. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. J. Neurochem. 72: 51-57, 1999. 2. Birdsong, W. T., Fierro, L., Williams, F. G., Spelta, V., Naves, L. A., Knowles, M., Marsh-Haffner, J., Adelman, J. P., Almers, W., Elde, R. P., McCleskey, E. W. Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron 68: 739-749, 2010. 3. de Weille, J. R., Bassilana, F., Lazdunski, M., Waldmann, R. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. FEBS Lett. 433: 257-260, 1998.

ASIC3

Acid-sensing ion channel 3

acid-sensing(proton-gated) ion channel 3

ACCN 3 antibody ACCN3 antibody ACCN3_HUMAN antibody Acid sensing ion channel 3 antibody Acid-sensing ion channel 3 antibody Amiloride sensitive cation channel 3 antibody Amiloride sensitive cation channel 3 testis antibody Amiloride-sensitive cation channel 3 antibody ASIC 3 antibody ASIC3 antibody DRASIC antibody hASIC 3 antibody hASIC3 antibody hTNaC 1 antibody hTNaC1 antibody Modulatory subunit of ASIC 2a antibody Modulatory subunit of ASIC2a antibody Neuronal amiloride sensitive cation channel 3 antibody Neuronal amiloride-sensitive cation channel 3 antibody Proton gated cation channel subunit antibody SLNAC 1 antibody SLNAC1 antibody Testis sodium channel 1 antibody TNaC 1 antibody TNaC1 antibody

Q9UHC3