Boster Immunoleader

antibody

Anti-KLF2 Antibody

PA1919

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-KLF2 Antibody

PA1919

Polyclonal

Rabbit IgG polyclonal antibody for Krueppel-like factor 2(KLF2) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of mouse KLF2(19-32aa ERGLQERWPRNEPE), identical to the related rat sequence and different from the related human sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

KLF2(Krueppel-like factor 2), also known as LKLF(LUNG KRUPPEL-LIKE ZINC FINGER TRANSCRIPTION FACTOR), is a protein that in humans is encoded by the KLF2 gene. Kruppel-like factors(KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1(S1PR1) and the selectin CD62L. Kozyrev et al.(1999) mapped the KLF2 gene to chromosome 19p13.13-p13.11, close to the KLF1 gene, by radiation hybrid analysis. Wani et al.(1999) mapped the KLF2 gene to 19p13.1 by somatic cell hybrid analysis and FISH. Buckley et al.(2001) showed that expression of LKLF in a T-cell line induced reversible quiescence resulting in marked inhibition of proliferation, decreases in cell size and protein synthesis, and reduced expression of activation markers. They concluded that LKLF functions, in part, by negatively regulating a MYC-dependent pathway.

1. Buckley, A. F., Kuo, C. T., Leiden, J. M. Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nature Immun. 2: 698-704, 2001. 2. Kozyrev, S. V., Hansen, L. L., Poltaraus, A. B., Domninsky, D. A., Kisselev, L. L. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. FEBS Lett. 448: 149-152, 1999. 3. Wani, M. A., Conkright, M. D., Jeffries, S., Hughes, M. J., Lingrel, J. B. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung Kruppel-like factor. Genomics 60: 78-86, 1999.

KLF2

Krueppel-like factor 2

Kruppel-like factor 2(lung)

KLF 2 antibody Klf2 antibody KLF2_HUMAN antibody Krueppel-like factor 2 antibody Kruppel like factor 2 antibody Kruppel like factor antibody Kruppel like factor LKLF antibody Kruppel-like factor 2(lung) antibody Lklf antibody Lung krueppel like factor antibody Lung krueppel-like factor antibody Lung Kruppel like zinc finger transcription factor antibody

Q60843