Boster Immunoleader

antibody

Anti-DLL1 Antibody

PA1911

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-DLL1 Antibody

PA1911

Polyclonal

Rabbit IgG polyclonal antibody for Delta-like protein 1(DLL1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

WB: The detection limit for DLL1 is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human DLL1(168-184aa RTDLKYSYRFVCDEHYY), different from the related rat and mouse sequences by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

DLL1(DELTA-LIKE 1) also known as DL1 or DELTA1, is a protein that in humans is encoded by the DLL1 gene. DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. Using FISH, Gray et al.(1999) mapped the DLL1 gene to chromosome 6q27, near a locus for type I diabetes. Functional analysis by Han et al.(2000) suggested that a soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal amino acids increased the viability of hemopoietic cells but inhibited cell death. Jaleco et al.(2001) used a cell coculture assay to show that DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. In contrast, JAG1 did not disturb either B-cell or T-cell/NK-cell development. Galceran et al. found that mouse Lef1 bound multiple sites in the Dll1 promoter in vitro and in vivo, and mutation of the Lef1 sites impaired expression of a reporter transgene in the presomitic mesoderm of embryonic mice.

1. Gray, G. E., Mann, R. S., Mitsiadis, E., Henrique, D., Carcangiu, M.-L., Banks, A., Leiman, J., Ward, D., Ish-Horowitz, D., Artavanis-Tsakonas, S. Human ligands of the Notch receptor. Am. J. Path. 154: 785-794, 1999. 2. Han, W., Ye, Q., Moore, M. A. S. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. Blood 95: 1616-1625, 2000. 3. Jaleco, A. C., Neves, H., Hooijberg, E., Gameiro, P., Clode, N., Haury, M., Henrique, D., Parreira, L. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 194: 991-1001, 2001.

DLL1

Delta-like protein 1

delta-like 1(Drosophila)

Delta(Drosophila) like 1 antibody Delta antibody Delta like 1(Drosophila) antibody Delta like 1 antibody Delta like 1 protein antibody Delta like protein 1 antibody Delta like protein 1 precursor antibody Delta, Drosophila, homolog of 1 antibody Delta-like protein 1 [Precursor] antibody Delta-like protein 1 antibody Delta1 antibody DL1 antibody DLL 1 antibody Dll1 antibody DLL1_HUMAN antibody Drosophila Delta homolog 1 antibody H-Delta-1 antibody OTTHUMP00000017690 antibody

O00548