Boster Immunoleader

antibody

Anti-GCSF Receptor Antibody

PA1906

100 ug/vial

200 USD

polyclonal

rabbit

Anti-GCSF Receptor Antibody

PA1906

Polyclonal

Rabbit IgG polyclonal antibody for Granulocyte colony-stimulating factor receptor(CSF3R) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for CSF3R is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor(254-271aa EPWQPGLHINQKCELRHK).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

CSF3R(Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor(G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

1. Dong, F., Qiu, Y., Yi, T., Touw, I. P., Larner, A. C. The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J. Immun. 167: 6447-6452, 2001. 2. Inazawa, J., Fukunaga, R., Seto, Y., Nakagawa, H., Misawa, S., Abe, T., Nagata, S. Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3. Genomics 10: 1075-1078, 1991. 3. Plo, I., Zhang, Y., Le Couedic, J.-P., Nakatake, M., Boulet, J.-M., Itaya, M., Smith, S. O., Debili, N., Constantinescu, S. N., Vainchenker, W., Louache, F., de Botton, S. An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J. Exp. Med. 206: 1701-1707, 2009.

CSF3R

Granulocyte colony-stimulating factor receptor

Colony stimulating factor 3 receptor(granulocyte)

CD 114 antibody CD114 antibody CD114 antigen antibody Colony stimulating factor 3 receptor(granulocyte) antibody Colony stimulating factor 3 receptor antibody CSF 3R antibody CSF3R antibody CSF3R_HUMAN antibody Csfgr antibody G CSF R antibody G-CSF receptor antibody G-CSF-R antibody GCSFR antibody Granulocyte colony stimulating factor receptor antibody Granulocyte colony stimulating factor receptor precursor antibody Granulocyte colony-stimulating factor receptor antibody OTTHUMP00000009703 antibody OTTHUMP00000009704 antibody OTTHUMP00000009705 antibody

Q99062