Anti-MCSF Receptor Antibody | Boster Immunoleader PA1905 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-MCSF Receptor Antibody

catalog :

PA1905

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

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product information

Product Name :

Anti-MCSF Receptor Antibody

Catalog Number :

PA1905

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Macrophage colony-stimulating factor 1 receptor(CSF1R) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

WB: The detection limit for CSF1R is approximately 2.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human MCSF Receptor(955-972aa EQGDIAQPLLQPNNYQFC), different from the related mouse sequence by one amino acid and from the related rat sequence by two amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

CSF1R(Colony-Stimulating Factor 1 Receptor) also known as MCSFR, FMS, c-FMS, CD115, ONCOGENE FMS or CD115 ANTIGEN, encodes a tyrosine kinase growth factor receptor for colony-stimulating factor-1, the macrophage-and monocyte-specific growth factor. The gene is located on long arm of chromosome 5(5q32) on the Crick(minus) strand. The as-yet-unidentified CSF1 Rpromoter/enhancer sequences may be confined to the nucleotides separating the 2 genes or could potentially lie within the PDGFR gene itself. The encoded protein is a single pass type I membrane protein and acts as the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. The encoded protein is atyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Kondo et al.(2000) showed that the endogenous myelomonocytic cytokine receptors for GM-CSF and macrophage colony-stimulating factor(CSF1R) are expressed at low to moderate levels on the more primitive hematopoietic stem cells, are absent on common lymphoid progenitors, and are upregulated after myeloid lineage induction by IL2.

Reference :

1. Aikawa, Y., Katsumoto, T., Zhang, P., Shima, H., Shino, M., Terui, K., Ito, E., Ohno, H., Stanley, E. R., Singh, H., Tenen, D. G., Kitabayashi, I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. (Letter) Nature Med. 16: 580-585, 2010. 2. Boultwood, J., Rack, K., Kelly, S., Madden, J., Sakaguchi, A. Y., Wang, L.-M., Oscier, D. G., Buckle, V. J., Wainscoat, J. S. Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion. Proc. Nat. Acad. Sci. 88: 6176-6180, 1991. 3. Kondo, M., Scherer, D. C., Miyamoto, T., King, A. G., Akashi, K., Sugamura, K., Weissman, I. L. Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines.Nature 407: 383-386, 2000.

Gene Name :

CSF1R

Protein Name :

Macrophage colony-stimulating factor 1 receptor

Gene Full Name :

Colony stimulating factor 1 receptor

Synonyms :

C FMS antibody CD 115 antibody CD115 antibody CD115 antigen antibody CFMS antibody Colony stimulating factor 1 receptor antibody Colony stimulating factor I receptor antibody CSF 1 R antibody CSF 1R antibody CSF-1 receptor antibody CSF-1-R antibody CSF1 R antibody CSF1R antibody CSF1R_HUMAN antibody CSFR antibody FIM 2 antibody FIM2 antibody FMS antibody FMS proto oncogene antibody FMS protooncogene antibody HDLS antibody M-CSF Receptor antibody M-CSF-R antibody Macrophage colony stimulating factor 1 receptor antibody Macrophage colony stimulating factor I receptor antibody Macrophage colony-stimulating factor 1 receptor antibody McDonough feline sarcoma viral(v fms) oncogene homolog antibody Oncogen FMS antibody Proto-oncogene c-Fms antibody V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody

Uniprot ID :

P07333

more info or order :

Boster Immunoleader product webpage