Boster Immunoleader

antibody

Anti-BOC Antibody

PA1904

100 ug/vial

200 USD

polyclonal

rabbit

Anti-BOC Antibody

PA1904

Polyclonal

Rabbit IgG polyclonal antibody for Brother of CDO(BOC) detection. Tested with WB in Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse Predicted to work with: rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse; Predicted Species: Rat

WB: The detection limit for BOC is approximately 1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of mouse BOC(1002-1020aa DDSTHQLLQPQDCCHLQKQ), identical to the related rat sequence.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

BOC(Brother Of CDO) also known as BROTHER OF CDON and BOC are cell surface receptors of the immunoglobulin(Ig)/fibronectin type III repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail. The domain structure of BOC is similar to that of CDON, and the 2 proteins share 38 to 80% amino acid identity in the individual extracellular domains. The International Radiation Hybrid Mapping Consortium mapped the BOC gene to chromosome 3. In contrast with CDON, the intracellular region of BOC was not essential for its ability to positively regulate differentiation.BOC is dependent on CDON for activity and that CDON-BOC complexes function to regulate myogenic differentiation. Wegorzewska et al.(2003) proposed that CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage.BOC is expressed by commissural neurons, and targeted disruption of BOC in mouse resulted in the misguidance of commissural axons toward the floor plate.

1. Kang, J.-S., Mulieri, P. J., Hu, Y., Taliana, L., Krauss, R. S. BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 21: 114-124, 2002. 2. Okada, A., Charron, F., Morin, S., Shin, D. S., Wong, K., Fabre, P. J., Tessier-Lavigne, M., McConnell, S. K. Boc is a receptor for Sonic hedgehog in the guidance of commissural axons. Nature 444: 369-373, 2006. 3. Wegorzewska, M., Krauss, R. S., Kang, J.-S. Overexpression of the immunoglobulin superfamily members CDO and BOCenhances differentiation of the human rhabdomyosarcoma cell line RD. Molec. Carcinogen. 37: 1-4, 2003.

BOC

Brother of CDO

BOC cell adhesion associated, oncogene regulated

Boc homolog(mouse) antibody Brother of CDO antibody Protein BOC antibody Protein BOC antibody

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