Boster Immunoleader

antibody

Anti-Transferrin Receptor 2 Antibody

PA1901

100 ug/vial

200 USD

polyclonal

rabbit

mouse, rat

Anti-Transferrin Receptor 2 Antibody

PA1901

Polyclonal

Rabbit IgG polyclonal antibody for Transferrin receptor protein 2(TFR2) detection. Tested with WB in Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of mouse Transferrin Receptor 2(1-15aa MEQRWGLLRRVQQWS), different from the related rat sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

TFR2(Transferrin receptor protein 2), is a protein that in humans is encoded by the TFR2 gene. This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated(PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. By radiation hybrid analysis, Kawabata et al.(1999) mapped the TFR2 gene to chromosome 7q22.The majority of hepatic iron uptake under normal circumstances is transferrin-mediated. However, expression of TFRC in hepatocytes, as in other nonreticuloendothelial cell types, is downregulated in response to increased intracellular iron. As a consequence, TFRC expression in liver is undetectable in hereditary hemochromatosis patients with hepatic iron loading. Nonetheless, hepatic iron loading in hemochromatosis patients is progressive. Fleming et al.(2000) provided support for a mechanism that involves the uptake of transferrin-bound iron by TFR2.

1. Fleming, R. E., Migas, M. C., Holden, C. C., Waheed, A., Britton, R. S., Tomatsu, S., Bacon, B. R., Sly, W. S.Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis.Proc. Nat. Acad. Sci. 97: 2214-2219, 2000. 2. Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F., Koeffler, H. P.Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family.J. Biol. Chem. 274: 20826-20832, 1999. 3. Mattman, A., Huntsman, D., Lockitch, G., Langlois, S., Buskard, N., Ralston, D., Butterfield, Y., Rodrigues, P., Jones, S., Porto, G., Marra, M., De Sousa, M., Vatcher, G.Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation.Blood 100: 1075-1077, 2002.

TFR2

Transferrin receptor protein 2

transferrin receptor 2

HFE 3 antibody HFE3 antibody MGC126368 antibody TFR 2 antibody TFR2 antibody TFR2_HUMAN antibody TFRC 2 antibody TFRC2 antibody Transferrin receptor 2 antibody Transferrin receptor protein 2 antibody

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