Anti-ErbB 4 Antibody | Boster Immunoleader PA1881 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-ErbB 4 Antibody

catalog :

PA1881

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

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product information

Availability :

info changed 20150325

Product Name :

Anti-ErbB 4 Antibody

Catalog Number :

PA1881

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for ERBB4 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4(35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.

Reference :

1. Huang, Y. Z., Won, S., Ali, D. W., Wang, Q., Tanowitz, M., Du, Q. S., Pelkey, K. A., Yang, D. J., Xiong, W. C., Salter, M. W., Mei, L. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26: 443-455, 2000. 2. Ni, C.-Y., Murphy, M. P., Golde, T. E., Carpenter, G.Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294: 2179-2181, 2001. 3. Sardi, S. P., Murtie, J., Koirala, S., Patten, B. A., Corfas, G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 127: 185-197, 2006.

Gene Name :

ERBB4

Protein Name :

Receptor tyrosine-protein kinase erbB-4

Gene Full Name :

v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian)

Synonyms :

4ICD antibody Avian erythroblastic leukemia viral oncogene homolog 4 antibody Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody E4ICD antibody EC 2.7.10.1 antibody ErbB4 antibody ERBB4 intracellular domain antibody ERBB4_HUMAN antibody HER 4 antibody HER4 antibody Mer4 antibody MGC138404 antibody Oncogene ERBB4 antibody P180erbB4 antibody Proto-oncogene-like protein c-ErbB-4 antibody Receptor protein tyrosine kinase erbB 4 precursor antibody Receptor tyrosine protein kinase erbB 4 antibody s80HER4 antibody Tyrosine kinase type cell surface receptor HER4 antibody Tyrosine kinase-type cell surface receptor HER4 antibody v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody v erb a erythroblastic leukemia viral oncogene homolog 4 antibody v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian) antibody V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody Verba erythroblastic leukemia viral oncogene homolog 4 antibody VERBB2 antibody

Uniprot ID :

Q15303

more info or order :

Boster Immunoleader product webpage