Boster Immunoleader

antibody

Anti-DDR2 Antibody

PA1879

100 ug/vial

200 USD

polyclonal

rabbit

Anti-DDR2 Antibody

PA1879

Polyclonal

Rabbit IgG polyclonal antibody for Discoidin domain-containing receptor 2(DDR2) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for DDR2 is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human DDR2(834-855aa RDTKNRPSFQEIHLLLLQQGDE), different from the related mouse sequence by three amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

DDR2(Discoidin domain receptor family, member 2) also known as NTRKR3 or TKT, is a human gene. Ddr2 protein was detected in most mouse tissues examined. Highest levels of phosphorylated Ddr2 were detected in lung, ovary, and skin, which did not correlate with Ddr2 protein levels. The DDR2 gene is mapped 1q23.3. Receptor tyrosine kinases(RTKs) play a key role in the communication of cells with their microenvironment.Using in situ hybridization with 1-week-old mice, Labrador et al.(2001) found that Ddr2 was expressed along chondrocyte columns in the proliferative region of the growth plate.Ddr2mRNA was also present, although dispersed, at areas of calcified cartilage in the cartilage-bone junction, as well as in the trabecular bone surface. Bargal et al.(2009) also identified a splice site mutation in the DDR2 gene, which resulted in the skipping of exon 17, in one of the Jewish families with SMED-SL originally reported by Borochowitz et al.(1993).

1. Bargal, R., Cormier-Daire, V., Ben-Neriah, Z., Le Merrer, M., Sosna, J., Melki, J., Zangen, D. H., Smithson, S. F., Borochowitz, Z., Belostotsky, R., Raas-Rothschild, A.Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. Am. J. Hum. Genet. 84: 80-84, 2009. 2. Borochowitz, Z., Langer, L. O., Jr., Gruber, H. E., Lachman, R., Katznelson, M. B.-M., Rimoin, D. L.Spondylo-meta-epiphyseal dysplasia (SMED), short limb-hand type: a congenital familial skeletal dysplasia with distinctive features and histopathology. Am. J. Med. Genet. 45: 320-326, 1993 3. Labrador, J. P., Azcoitia, V., Tuckermann, J., Lin, C., Olaso, E., Manes, S., Bruckner, K., Goergen, J.-L., Lemke, G., Yancopoulos, G., Angel, P., Martinez-A, C., Klein, R.The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO J. 2: 446-452, 2001.

DDR2

Discoidin domain-containing receptor 2

discoidin domain receptor tyrosine kinase 2

CD167 antigen-like family member B antibody CD167b antibody CD167b antigen antibody Cell migration inducing protein 20 antibody DDR 2 antibody DDR2 antibody DDR2_HUMAN antibody Discoidin domain containing receptor 2 antibody Discoidin domain receptor 2 antibody Discoidin domain receptor family member 2 antibody discoidin domain receptor tyrosine kinase 2 antibody Discoidin domain-containing receptor 2 antibody discoidin domain-containing receptor tyrosine kinase 2 antibody Hydroxyaryl protein kinase antibody MIG20a antibody Migration inducing gene 16 protein antibody Neurotrophic tyrosine kinase antibody Neurotrophic tyrosine kinase receptor related 3 antibody NTRKR 3 antibody NTRKR3 antibody Receptor protein tyrosine kinase TKT antibody Receptor protein-tyrosine kinase TKT antibody Receptor related 3 antibody receptor-related 3 antibody TKT antibody TYRO 10 antibody TYRO10 antibody Tyrosine kinase receptor related to neurotrophic TRK antibody Tyrosine protein kinase TYRO 10 antibody Tyrosine protein kinase TYRO10 antibody Tyrosine-protein kinase TYRO10 antibody Tyrosylprotein kinase antibody

Q16832