Anti-MCK10 Antibody | Boster Immunoleader PA1878 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-MCK10 Antibody

catalog :

PA1878

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

western blot

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product information

Product Name :

Anti-MCK10 Antibody

Catalog Number :

PA1878

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Epithelial discoidin domain-containing receptor 1(DDR1) detection. Tested with WB in Human;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human Predicted to work with: rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Rat

Notes :

WB: The detection limit for DDR1 is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human MCK10(898-913aa FSQLHRFLAEDALNTV), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

DDR1(Discoidin domain receptor family, member 1) also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain.The DDR1 gene is mapped on 6p21.33. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al.(2000) showed that Ddr1 was highly expressed in the cerebellum of developing and adult mouse brain, and that both Ddr1 and collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of collagen I- and IV-expressing mouse pial cells with Ddr1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-Ddr1signaling reduced granule cell neurite elongation.

Reference :

1. Bhatt, R. S., Tomoda, T., Fang, Y., Hatten, M. E.Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 14: 2216-2228, 2000. 2. Edelhoff, S., Sweetser, D. A., Disteche, C. M. Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. Genomics 25: 309-311, 1995. 3. Hou, G., Vogel, W., Bendeck, M. P. The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J. Clin. Invest. 107: 727-735, 2001.

Gene Name :

DDR1

Protein Name :

Epithelial discoidin domain-containing receptor 1

Gene Full Name :

discoidin domain receptor tyrosine kinase 1

Synonyms :

CAK antibody CD 167 antibody CD167 antibody CD167 antigen-like family member A antibody CD167a antibody Cell adhesion kinase antibody DDR 1 antibody DDR antibody DDR1 antibody DDR1_HUMAN antibody Discoidin domain receptor antibody Discoidin domain receptor tyrosine kinase 1 antibody Discoidin receptor tyrosine kinase antibody Discoidin receptor tyrosine kinase isoform a antibody EDDR 1 antibody EDDR1 antibody Epithelial discoidin domain receptor 1 antibody Epithelial discoidin domain-containing receptor 1 antibody Epithelial specific receptor kinase antibody HGK2 antibody Mammarian carcinoma kinase 10 antibody Mammary carcinoma kinase 10 antibody MCK-10 antibody MCK10 antibody NEP antibody Neuroepithelial tyrosine kinase antibody Neurotrophic tyrosine kinase receptor type 4 antibody NTRK 4 antibody NTRK4 antibody OTTHUMP00000029343 antibody OTTHUMP00000029344 antibody OTTHUMP00000029345 antibody OTTHUMP00000029346 antibody OTTHUMP00000029347 antibody OTTHUMP00000164863 antibody OTTHUMP00000164867 antibody OTTHUMP00000222080 antibody Protein-tyrosine kinase 3A antibody Protein-tyrosine kinase RTK-6 antibody PTK 3 antibody PTK 3A protein tyrosine kinase 3A antibody PTK3 antibody PTK3A antibody Receptor tyrosine kinase NEP antibody RTK 6 antibody RTK6 antibody TRK E antibody TRKE antibody Tyrosine kinase DDR antibody Tyrosine kinase receptor E antibody Tyrosine-protein kinase CAK antibody

Uniprot ID :

Q08345

more info or order :

Boster Immunoleader product webpage