Boster Immunoleader

antibody

Anti-CD1a Antibody

PA1875

100 ug/vial

200 USD

polyclonal

rabbit

Anti-CD1a Antibody

PA1875

Polyclonal

Rabbit IgG polyclonal antibody for T-cell surface glycoprotein CD1a(CD1A) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for CD1A is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human CD1a(158-173aa AKHFCKVLNQNQHEND).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

CD1A(Thymocyte antigen CD1A) also known as CD1, is a human protein encoded by the CD1A gene. CD1A is 1 of 5 distinct CD1 genes that are variably conserved in different mammalian species. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex(MHC) proteins and form heterodimers with beta-2-microglobulin.The CD1A gene is mapped on 1q23.1. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. CD1A is concentrated in the early or recycling endosome. Moody et al.(2004) reported that CD1A presents to T cells a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Apolipoprotein E(107741) binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells.

1. Martin, L. H., Calabi, F., Lefebvre, F.-A., Bilsland, C. A. G., Milstein, C. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.Proc. Nat. Acad. Sci. 84: 9189-9193, 1987. 2. Moody, D. B., Young, D. C., Cheng, T.-Y., Rosat, J.-P., Roura-mir, C., O'Connor, P. B., Zajonc, D. M., Walz, A., Miller, M. J., Levery, S. B., Wilson, I. A., Costello, C. E., Brenner, M. B. T cell activation by lipopeptide antigens. Science 303: 527-531, 2004. Note: Erratum: Science 304: 211 only, 2004. 3. Park, S.-H., Bendelac, A. CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792, 2000.

CD1A

T-cell surface glycoprotein CD1a

CD1a molecule

CD 1a antibody CD1 antibody CD1a antibody CD1A antibody CD1A Antigen antibody CD1A antigen, a polypeptide antibody CD1a molecule antibody CD1A_HUMAN antibody cluster of differentiation 1 A antibody Cortical thymocyte antigen CD1A antibody differentiation antigen CD1 alpha 3 antibody Epidermal dendritic cell marker CD1a antibody FCB 6 antibody FCB6 antibody HTA 1 antibody HTA1 antibody hTa1 thymocyte antigen antibody OTTHUMP00000018907 antibody R 4 antibody R4 antibody T 6 antibody T Cell Surface Antigen Leu 6 antibody T Cell Surface Antigen T6 antibody T cell surface antigen T6/Leu 6 antibody T Cell Surface Glycoprotein CD1A antibody T-cell surface antigen T6/Leu-6 antibody T-cell surface glycoprotein CD1a antibody T6 antibody Thymocyte Antigen CD1A antibody

P06126