Boster Immunoleader

antibody

Anti-ABCG1 Antibody

PA1868

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-ABCG1 Antibody

PA1868

Polyclonal

Rabbit IgG polyclonal antibody for ATP-binding cassette sub-family G member 1(ABCG1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

WB: The detection limit for ABCG1 is approximately 5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human ABCG1(627-647aa ETCHFQKSEAILRELDVENAK), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

ABCG1(Atp-binding cassette, subfamily g, member 1) also known as ABC8, ABC TRANSPORTER 8 or WHITE, DROSOPHILA, HOMOLOG OF, is a protein that in humans is encoded by the ABCG1 gene. ABCG1 is a regulator of macrophage cholesterol and phospholipid transport. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette(ABC) transporters.The ABCG1 gene is mapped on 21q22.3. This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. ABCG1 is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. Inhibition of ABCG1 protein expression using an antisense strategy resulted in reduced HDL3-dependent efflux of cholesterol and choline-phospholipids. In macrophages, silencing of GPS2 by RNA interference reduced ABCG1 expression and diminished ABCG1-mediated cholesterol efflux.

1. Chen, H., Rossier, C., Lalioti, M. D., Lynn, A., Chakravarti, A., Perrin, G., Antonarakis, S. E. Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. Am. J. Hum. Genet. 59: 66-75, 1996. 2. Jakobsson, T., Venteclef, N., Toresson, G., Damdimopoulos, A. E., Ehrlund, A., Lou, X., Sanyal, S., Steffensen, K. R., Gustafsson, J.-A., Treuter, E. GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. Molec. Cell 34: 510-518, 2009. 3. Lorkowski, S., Rust, S., Engel, T., Jung, E., Tegelkamp, K., Galinski, E. A., Assmann, G., Cullen, P. Genomic sequence and structure of the human ABCG1(ABC8) gene. Biochem. Biophys. Res. Commun. 280: 121-131, 2001.

ABCG1

ATP-binding cassette sub-family G member 1

ATP-binding cassette, sub-family G(WHITE), member 1

ABC transporter 8 antibody Abc8 antibody ABCG1 antibody ABCG1_HUMAN antibody ATP-binding cassette sub family G member 1 antibody ATP-binding cassette sub-family G member 1 antibody ATP-binding cassette transporter 8 antibody ATP-binding cassette transporter member 1 of subfamily G antibody ATP-binding cassette, sub family G WHITE member 1 antibodyhomolog of Drosophila white antibody MGC34313 antibody White protein homolog antibody White protein homolog ATP binding cassette transporter 8 antibody WHITE1 antibody wht1 antibody

P45844