Boster Immunoleader

antibody

Anti-TGF beta Receptor II Antibody

PA1866

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-TGF beta Receptor II Antibody

PA1866

Polyclonal

Rabbit IgG polyclonal antibody for TGF-beta receptor type-2(TGFBR2) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

WB: The detection limit for TGFBR2 is approximately 2.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human TGF beta Receptor II(330-346aa KGNLQEYLTRHVISWED), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

TGFBR2(transforming growth factor, beta receptor II(70/80kDa)), also known as TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II(TGF-beta receptor type II, TbetaR-II), is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. A TGFBR2 cDNA encoding a deduced 565-amino acid protein with a calculated molecular mass of approximately 60 kD in length. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. TGFBR2 may be a target of the EWS-FLI1 fusion protein found in Ewing sarcoma and related peripheral primitive neuroectodermal tumors.

1. Hagen, G., Muller, S., Beato, M., Suske, G. Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes. Nucleic Acids Res. 20: 5519-5525, 1992. 2. Lin, H. Y., Wang, X.-F., Ng-Eaton, E., Weinberg, R. A., Lodish, H. F. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell 68: 775-785, 1992. 3. Hahm, K.-B., Cho, K., Lee, C., Im, Y.-H., Chang, J., Choi, S.-G., Sorensen, P. H. B., Thiele, C. J., Kim, S.-J.Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nature Genet. 23: 222-227, 1999.

TGFBR2

TGF-beta receptor type-2(TGFR-2)

transforming growth factor, beta receptor II(70/80kDa)

AAT 3 antibody AAT3 antibody FAA 3 antibody FAA3 antibody HNPCC6 antibody LDS1B antibody LDS2B antibody MFS 2 antibody MFS2 antibody RIIC antibody TAAD 2 antibody TAAD2 antibody TbetaR II antibody TbetaR-II antibody TGF beta receptor type 2 antibody TGF beta receptor type II antibody TGF beta receptor type IIB antibody TGF beta type II receptor antibody TGF-beta receptor type II antibody TGF-beta receptor type-2 antibody TGF-beta type II receptor antibody TGFB R2 antibody TGFbeta RII antibody TGFBR 2 antibody TGFBR2 antibody TGFR 2 antibody TGFR-2 antibody TGFR2 antibody TGFR2_HUMAN antibody Transforming growth factor beta receptor II antibody Transforming growth factor beta receptor type II antibody Transforming growth factor beta receptor type IIC antibody Transforming growth factor-beta receptor type II antibody

P37173