Boster Immunoleader

antibody

Anti-Peroxiredoxin 2 Antibody

PA1834

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-Peroxiredoxin 2 Antibody

PA1834

Polyclonal

Rabbit IgG polyclonal antibody for Peroxiredoxin-2(PRDX2) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 2(181-198aa DTIKPNVDDSKEYFSKHN), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

PRDX2(peroxiredoxin 2) also known as NKEFB, PRP, PRX2, PRXII or TPX1, is a protein that in humans is encoded by the PRDX2 gene. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The Prdx2 -/- mice were healthy in appearance and fertile. Choi et al.(2005) demonstrated that PRDX2 is a negative regulator of PDGF signaling. Prx II deficiency results in increased production of peroxide, enhanced activation of PDGF receptor and phospholipase C-gamma-1, and subsequently increased cell proliferation and migration in response to PDGF. PRX2 accounted for about half of the thioredoxin activity in parasite extracts, and PRX2 expression was increased in the presence of chloroquine, regardless of P. falciparum strain susceptibility to the drug.

1. Choi, M. H., Lee, I. K., Kim, G. W., Kim, B. U., Han, Y.-H., Yu, D.-Y., Park, H. S., Kim, K. Y., Lee, J. S., Choi, C., Bae, Y. S., Lee, B. I., Rhee, S. G., Kang, S. W. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435: 347-353, 2005. 2. Lee, T.-H., Kim, S.-U., Yu, S.-L., Kim, S. H., Park, D. S., Moon, H.-B., Dho, S. H., Kwon, K.-S., Kwon, H. J., Han, Y.-H., Jeong, S., Kang, S. W., Shin, H.-S., Lee, K.-K., Rhee, S. G., Yu, D.-Y. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood 101: 5033-5038, 2003. 3. Pahl, P., Berger, R., Hart, I., Chae, H. Z., Rhee, S. G., Patterson, D. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. Genomics 26: 602-606, 1995.

PRDX2

Peroxiredoxin-2

peroxiredoxin 2

MGC4104 antibody Natural killer cell enhancing factor B antibody Natural killer cell-enhancing factor B antibody Natural Killer Enhancing Factor B antibody NKEF B antibody NKEF-B antibody NKEFB antibody Peroxiredoxin-2 antibody PRDX 2 antibody PRDX2 antibody PRDX2_HUMAN antibody PrP antibody PRX2 antibody PRXII antibody TDPX1 antibody Thiol Specific Antioxidant 1 antibody Thiol specific antioxidant protein antibody Thiol-specific antioxidant protein antibody Thioredoxin Dependent Peroxide Reductase 1 antibody Thioredoxin peroxidase 1 antibody Thioredoxin-dependent peroxide reductase 1 antibody Torin antibody TPX1 antibody TSA antibody

P32119