Boster Immunoleader

antibody

Anti-MEF2C Antibody

PA1824

100 ug/vial

200 USD

polyclonal

rabbit

human, rat

western blot, immunohistochemistry - paraffin section

Anti-MEF2C Antibody

PA1824

Polyclonal

Rabbit IgG polyclonal antibody for Myocyte-specific enhancer factor 2C(MEF2C) detection. Tested with WB, IHC-P in Human;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human MEF2C(406-419aa SRYPQHTRHEAGRS), identical to the related rat sequence.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

MEF2C(myocyte enhancer factor 2C) also called  MADS box transcription enhancer factor 2, polypeptide C, is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.MEF2C, however, is induced late during myogenic differentiation and has a strict tissue-specific pattern of expression not seen in MEF2A or MEF2B. By fluorescence in situ hybridization, the human MEF2C is mapped to chromosome 5q14, a region with homology of synteny to the mouse location.MEF2C may be involved with maintenance of the differentiated state. Both MEF2A and Mef2c programmed similar profiles of gene expression in the heart that included genes involved in extracellular matrix remodeling, ion handling, and metabolism. NCOA2 mediates the coactivation of MEF2C-dependent transcription through interaction with the MADS box domain of MEF2C.

1. Barbosa, A. C., Kim. M.-S., Ertunc, M., Adachi, M., Nelson, E. D., McAnally, J., Richardson, J. A., Kavalali, E. T., Monteggia, L. M., Bassel-Duby, R., Olson, E. N. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc. Nat. Acad. Sci. 105: 9391-9396, 2008. 2. Chen, S. L., Dowhan, D. H., Hosking, B. M., Muscat, G. E. O. The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation. Genes Dev. 14: 1209-1228, 2000. 3. Krainc, D., Haas, M., Ward, D. C., Lipton, S. A., Bruns, G., Leifer, D. Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved. Genomics 29: 809-811, 1995.

MEF2C

Myocyte-specific enhancer factor 2C

myocyte enhancer factor 2C

C5DELq14.3 antibody DEL5q14.3 antibody MADS box transcription enhancer factor 2 polypeptide C(myocyte enhancer factor 2C) antibody MEF2C antibody MEF2C_HUMAN antibody Myocyte enhancer factor 2C antibody Myocyte specific enhancer factor 2C antibody Myocyte-specific enhancer factor 2C antibody OTTHUMP00000222409 antibody Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

Q06413