Anti-Prion protein PrP Antibody | Boster Immunoleader PA1794 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Prion protein PrP Antibody

catalog :

PA1794

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Prion protein PrP Antibody

Catalog Number :

PA1794

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Major prion protein(PRNP) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human Prion protein PrP(144-160aa DYEDRYYRENMHRYPNQ).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

PRNP(prion protein), also known as CD230 and PRP, is a protein that in humans is encoded by the PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett et al.(1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP gene, which might serve as a useful marker for the pter-p12 region of chromosome 20. PRNP is associated with a variety of cognitive deficiencies and neurodegenerative diseases such as Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved through mammals, lending credence to application of conclusions from test animals such as mice. Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid sequences.

Reference :

1. Bounhar, Y., Zhang, Y., Goodyer, C. G., LeBlanc, A.Prion protein protects human neurons against Bax-mediated apoptosis.J. Biol. Chem. 276: 39145-39149, 2001. 2. Brown, P., Galvez, S., Goldfarb, L. G., Nieto, A., Cartier, L., Gibbs, C. J., Jr., Gajdusek, D. C.Familial Creutzfeldt-Jakob disease in Chile is associated with the codon 200 mutation of the PRNP amyloid precursor gene on chromosome 20.J. Neurol. Sci. 112: 65-67, 1992. 3. Puckett, C., Concannon, P., Casey, C., Hood, L.Genomic structure of the human prion protein gene.Am. J. Hum. Genet. 49: 320-329, 1991.

Gene Name :

PRNP

Protein Name :

Major prion protein(PrP)

Gene Full Name :

prion protein

Synonyms :

Alternative prion protein; major prion protein antibody AltPrP antibody ASCR antibody atal familial insomnia antibody CD230 antibody CD230 antigen antibody CJD antibody Creutzfeld Jakob disease antibody Creutzfeld Jakob Disease Gerstmann Strausler Scheinker Syndrome Fatal Familial Insomnia antibody Gerstmann-Strausler-Scheinker syndrome antibody GSS antibody KURU antibody Major prion protein antibody MGC26679 antibody p27 30 antibody PRIO_HUMAN antibody Prion protein antibody Prion related protein antibody PRIP antibody Prni antibody Prnp antibody PrP 27-30 antibody PrP antibody PrP27 30 antibody PrP27-30 antibody PrP33 35C antibody PrP33-35C antibody PrPC antibody PrPSc antibody Sinc antibody

Uniprot ID :

P04156

more info or order :

Boster Immunoleader product webpage