Boster Immunoleader

antibody

Anti-ATM Antibody

PA1784

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-ATM Antibody

PA1784

Polyclonal

Rabbit IgG polyclonal antibody for Serine-protein kinase ATM(ATM) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human ATM(36-50aa DPETIKHLDRHSDSK), different from the related rat and mouse sequences by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

ATM(ataxia telangiectasia mutated),also known as TEL1 or TELO1, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. Linkage analysis of ataxia-telangiectasia led to mapping of the ATM gene to chromosome 11q22.3. Using an antiserum developed to a peptide corresponding to the deduced amino acid sequence of ATM, the ATM protein is a single, high molecular weight protein predominantly confined to the nucleus of human fibroblasts, although it is present in both nuclear and microsomal fractions from human lymphoblast cells and peripheral blood lymphocytes. Overexpression of ATM cDNA in AT cells enhanced their survival after radiation exposure, decreased radiation-induced chromosome aberrations, reduced radioresistant DNA synthesis, and partially corrected defective cell cycle checkpoints and induction of stress-activated protein kinase. ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner. ATM functions directly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly.

1. Allen, D. M., van Praag, H., Ray, J., Weaver, Z., Winrow, C. J., Carter, T. A., Braquet, R., Harrington, E., Ried, T., Brown, K. D., Gage, F. H., Barlow, C. Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev. 15: 554-566, 2001. 2. Bakkenist, C. J., Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.Nature 421: 499-506, 2003. 3. Chong, M. J., Murray, M. R., Gosink, E. C., Russell, H. R. C., Srinivasan, A., Kapsetaki, M., Korsmeyer, S. J., McKinnon, P. J. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc. Nat. Acad. Sci. 97: 889-894, 2000.

ATM

Serine-protein kinase ATM

ataxia telangiectasia mutated

A-T mutated antibody A-T mutated homolog antibody AT complementation group A antibody AT complementation group C antibody AT complementation group D antibody AT complementation group E antibody AT mutated antibody AT protein antibody AT1 antibody ATA antibody Ataxia telangiectasia gene mutated in human beings antibody Ataxia telangiectasia mutated antibody Ataxia telangiectasia mutated gene antibody Ataxia telangiectasia mutated homolog(human) antibody Ataxia telangiectasia mutated homolog antibody ATC antibody ATD antibody ATDC antibody ATE antibody ATM antibody ATM_HUMAN antibody DKFZp781A0353 antibody Human phosphatidylinositol 3 kinase homolog antibody MGC74674 antibody OTTHUMP00000232981 antibody Serine protein kinase ATM antibody Serine-protein kinase ATM antibody Serine/threonine-protein kinase ATM antibody T cell prolymphocytic leukemia antibody Tefu antibody TEL1 antibody TEL1, telomere maintenance 1, homolog antibody TELO1 antibody Telomere fusion protein antibody TPLL antibody

Q13315