Boster Immunoleader

antibody

Anti-Dysadherin Antibody

PA1765

100 ug/vial

200 USD

polyclonal

rabbit

western blot, immunohistochemistry - paraffin section

Anti-Dysadherin Antibody

PA1765

Polyclonal

Rabbit IgG polyclonal antibody for FXYD domain-containing ion transport regulator 5(FXYD5) detection. Tested with WB, IHC-P in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Dysadherin(165-188aa KCRQLSRLCRNRCR).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression.

1. Ino, Y., Gotoh, M., Sakamoto, M., Tsukagoshi, K., Hirohashi, S. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc. Nat. Acad. Sci. 99: 365-370, 2002. 2. Omasa, T., Chen, Y.-G., Mantalaris, A., Wu, J. H. D. A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1-gamma-1/PLM/MAT8 family of transmembrane proteins. Biochim. Biophys. Acta 1517: 307-310, 2001. 3. Sweadner, K. J., Rael, E. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics 68: 41-56, 2000.

FXYD5

FXYD domain-containing ion transport regulator 5

FXYD domain containing ion transport regulator 5

Dysad antibody Dysadherin antibody FXYD 5 antibody FXYD domain containing ion transport regulator 5 antibody FXYD domain-containing ion transport regulator 5 antibody Fxyd5 antibody FXYD5_HUMAN antibody FXYD5RIC antibody HSPC 113 antibody HSPC113 antibody IWU 1 antibody IWU1 antibody KCT 1 antibody KCT1 antibody Keratinocytes associated transmembrane protein 1 antibody OIT 2 antibody OIT2 antibody PRO 6241 antibody PRO6241 antibody RIC antibody

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