Boster Immunoleader

antibody

Anti-Granzyme B Antibody

PA1738

100 ug/vial

200 USD

polyclonal

rabbit

Anti-Granzyme B Antibody

PA1738

Polyclonal

Rabbit IgG polyclonal antibody for Granzyme B(GZMB) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme B(168-184aa QEDRKCESDLRHYYDST).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes(CTL) and natural killer(NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are though to protect their host by inducing apoptosis of cells that bear on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

1. Huang, C., Bi, E., Hu. Y., Deng, W., Tian, Z., Dong, C., Hu, Y., Sun, B.A novel NF-kappa-B binding site controls human granzyme B gene transcription.J. Immun. 176: 4173-4181, 2006. 2. Motyka, B., Korbutt, G., Pinkoski, M. J., Heibein, J. A., Caputo, A., Hobman, M., Barry, M., Shostak, I., Sawchuk, T., Holmes, C. F. B., Gauldie, J., Bleackley, R. C.Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.Cell 103: 491-500, 2000. 3. Winrow, C. J., Pankratz, D. G., Vibat, C. R. T., Bowen, T. J., Callahan, M. A., Warren, A. J., Hilbush, B. S., Wynshaw-Boris, A., Hasel, K. W., Weaver, Z., Lockhart, D. J., Barlow, C.Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.Hum. Molec. Genet. 14: 2671-2684, 2005.

GZMB

Granzyme B

granzyme B(granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

C11 antibody Cathepsin G like 1 antibody Cathepsin G-like 1 antibody CCPI antibody CGL 1 antibody CGL1 antibody CSP B antibody CSPB antibody CTLA-1 antibody CTLA1 antibody CTSGL1 antibody Cytotoxic serine protease B antibody Cytotoxic T lymphocyte associated serine esterase 1 antibody Cytotoxic T lymphocyte proteinase 2 antibody Cytotoxic T-lymphocyte proteinase 2 antibody Fragmentin 2 antibody Fragmentin-2 antibody GRAB_HUMAN antibody Granzyme 2 antibody Granzyme B(granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody Granzyme B antibody Granzyme-2 antibody GranzymeB antibody GRB antibody Gzmb antibody Hlp antibody Human lymphocyte protein antibody Lymphocyte protease antibody Protease, serine, B antibody SECT antibody T cell serine protease 1-3E antibody T-cell serine protease 1-3E antibody

P10144