Anti-TGF beta Receptor I Antibody | Boster Immunoleader PA1731 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TGF beta Receptor I Antibody

catalog :

PA1731

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

application :

western blot, immunohistochemistry - paraffin section

publications citing this reagent :

Li Y, Gu J, Zou X, Wu J, Zhang M, Jiang J, et al. The anti-lung cancer activities of steroidal saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through enhanced immunostimulation in experimental Lewis tumor-bearing C57BL/6 mice and induction of apoptosis in the A549 cell line. Molecules. 2013;18:12916-36 pubmed publisher
Feng L, Zhu M, Zhang M, Jia X, Cheng X, Ding S, et al. Amelioration of compound 4,4'-diphenylmethane-bis(methyl)carbamate on high mobility group box1-mediated inflammation and oxidant stress responses in human umbilical vein endothelial cells via RAGE/ERK1/2/NF-κB pathway. Int Immunopharmacol. 2013;15:206-16 pubmed publisher
Ma Y, Sun D, Li J, Yin Z. Transplantation of endothelial progenitor cells alleviates renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction. Life Sci. 2010;86:798-807 pubmed publisher
Ren Z, Tong Y, Xu W, Ma J, Chen Y. Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression. Phytomedicine. 2010;17:212-8 pubmed publisher
Zhu C, Ying D, Zhou D, Mi J, Zhang W, Chang Q, et al. Expression of TGF-beta1 in smooth muscle cells regulates endothelial progenitor cells migration and differentiation. J Surg Res. 2005;125:151-6 pubmed

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product information

Product Name :

Anti-TGF beta Receptor I Antibody

Catalog Number :

PA1731

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for TGF-beta receptor type-1(TGFBR1) detection. Tested with WB, IHC-P in Human;Rat;Mouse.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human TGF beta Receptor I(281-295aa DYHEHGSLFDYLNRY), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

TGFBR1, Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome(LDAS). TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss(1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons. The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family.

Reference :

1. Drera, B., Tadini, G., Barlati, S., Colombi, M.Identification of a novel TGFBR1 mutation in a Loeys-Dietz syndrome type II patient with vascular Ehlers-Danlos syndrome phenotype. (Letter)Clin. Genet. 73: 290-293, 2008. 2. Goudie, D. R., D'Alessandro, M., Merriman, B., Lee, H., Szeverenyi, I., Avery, S., O'Connor, B. D., Nelson, S. F., Coats, S. E., Stewart, A., Christie, L., Pichert, G., and 11 others.Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1.Nature Genet. 43: 365-369, 2011. 3. Vellucci, V. F., Reiss, M.Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene.Genomics 46: 278-283, 1997.

Gene Name :

TGFBR1

Protein Name :

TGF-beta receptor type-1(TGFR-1)

Gene Full Name :

transforming growth factor, beta receptor 1

Synonyms :

AAT 5 antibody AAT5 antibody Activin A receptor type II like kinase 53kDa antibody Activin A receptor type II like kinase, 53kD antibody Activin A receptor type II like protein kinase of 53kD antibody activin A receptor type II-like kinase, 53kDa antibody activin A receptor type II-like protein kinase of 53kD antibody Activin receptor like kinase 5 antibody Activin receptor-like kinase 5 antibody ACVRLK 4 antibody ACVRLK4 antibody ALK 5 antibody ALK-5 antibody ALK5 antibody LDS1A antibody LDS2A antibody MSSE antibody Serine/threonine protein kinase receptor R4 antibody Serine/threonine-protein kinase receptor R4 antibody SKR 4 antibody SKR4 antibody TbetaR I antibody TbetaR-I antibody TGF beta receptor type 1 antibody TGF beta receptor type I antibody TGF beta type I receptor antibody TGF-beta receptor type I antibody TGF-beta receptor type-1 antibody TGF-beta type I receptor antibody TGFBR 1 antibody TGFBR1 antibody TGFBR1 protein antibody TGFR 1 antibody TGFR-1 antibody TGFR1 antibody TGFR1_HUMAN antibody Transforming growth factor beta receptor 1 antibody Transforming growth factor beta receptor I(activin A receptor type II like kinase, 53kD) antibody Transforming growth factor beta receptor I antibody transforming growth factor, beta receptor 1 antibody transforming growth factor, beta receptor I(activin A receptor type II-like kinase, 53kD) antibody Transforming growth factor-beta receptor type I antibody

Uniprot ID :

P36897

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