Boster Immunoleader

antibody

Anti-SDHA Antibody

PA1717

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-SDHA Antibody

PA1717

Polyclonal

Rabbit IgG polyclonal antibody for Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial(SDHA) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human SDHA(113-128aa NMEEDNWRWHFYDTVK), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

SDHA(Succinate dehydrogenase complex, subunit a, flavoprotein), also called SDH1, HOMOLOG OF, is a protein that in humans is encoded by the SDHA gene. The SDHA gene is mapped on 5p15.33. The SDHA gene is highly polymorphic. The gene that codes for the SDHA protein is nuclear, even though the protein is located in the inner membrane of the mitochondria. Heterozygous carriers of an SDHA mutation do not developparagangliomas as has been seen for mutations in the other subunits. In vitro functional expression studies in the yeast homolog showed that the mutation resulted in a loss of SDH activity and rendered the mutant SDHA protein more susceptible to proteolysis. The findings indicated that SDHA, like other SDH subunits, can act as a tumor suppressor gene.

1. DiMauro, S., Schon, E. A. Nuclear power and mitochondrial disease. Nature Genet. 19: 214-215, 1998. 2. Hirawake, H., Wang, H., Kuramochi, T., Kojima, S., Kita, K. Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria. J. Biochem. 116: 221-227, 1994. 3. Morris, A. A. M., Farnsworth, L., Ackrell, B. A. C., Turnbull, D. M., Birch-Machin, M. A. The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase. Biochim. Biophys. Acta 1185: 125-128, 1994.

SDHA

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

succinate dehydrogenase complex, subunit A, flavoprotein(Fp)

CMD1GG antibody DHSA_HUMAN antibody Flavoprotein subunit of complex II antibody Fp antibody PGL5 antibody SDH 2 antibody SDH1 antibody SDH2 antibody SDHA antibody SDHF antibody Succinate dehydrogenase[ubiquinone] flavoprotein subunit antibody Succinate dehydrogenase[ubiquinone] flavoprotein subunit mitochondrial antibody Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial antibody Succinate dehydrogenase complex flavoprotein subunit antibody Succinate dehydrogenase complex flavoprotein subunit precursor antibody Succinate dehydrogenase complex subunit A antibody Succinate Dehydrogenase Complex subunit A Flavoprotein antibody

P31040