Boster Immunoleader

antibody

Anti-Telomerase Antibody

PA1696

100 ug/vial

200 USD

polyclonal

rabbit

mouse, rat

Anti-Telomerase Antibody

PA1696

Polyclonal

Rabbit IgG polyclonal antibody for Telomerase reverse transcriptase(TERT) detection. Tested with WB in Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of mouse Telomerase(15-30aa RSRYREVWPLATFVRR), identical to the related rat sequence.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

TERT(Telomerase reverse transcriptase), is a catalytic subunit of the enzyme telomerase. Its absence(usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat. The TERT gene was mapped to chromosome 5p15.33T by Meyerson, M. Elomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells, resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

1. Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., Weinberg, R. A.hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.Cell 90: 785-795, 1997. 2. Morales, C. P., Holt, S. E., Ouellette, M., Kaur, K. J., Yan, Y., Wilson, K. S., White, M. A., Wright, W. E., Shay, J. W.Absence of cancer-associated changes in human fibroblasts immortalized with telomerase.Nature Genet. 21: 115-118, 1999. 3. Oh, H., Taffet, G. E., Youker, K. A., Entman, M. L., Overbeck, P. A., Michael, L. H., Schneider, M. D.Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival.Proc. Nat. Acad. Sci. 98: 10308-10313, 2001.

TERT

Telomerase reverse transcriptase

telomerase reverse transcriptase

EST2 antibody hEST2 antibody htert antibody TCS1 antibody Telomerase associated protein 2 antibody Telomerase Catalytic Subunit antibody Telomerase reverse transcriptase antibody Telomerase-associated protein 2 antibody Telomere Reverse Transcriptase antibody TERT antibody TERT_HUMAN antibody TP2 antibody TRT antibody

O70372