Boster Immunoleader

antibody

Anti-Somatostatin Receptor 2 Antibody

PA1694

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-Somatostatin Receptor 2 Antibody

PA1694

Polyclonal

Rabbit IgG polyclonal antibody for Somatostatin receptor type 2(SSTR2) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: rat Predicted to work with: human, mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human Somatostatin Receptor 2(184-198aa RSNQWGRSSCTINWP), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

SSTR2(Somatostatin receptor type 2) is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable SSTR2 transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin.SSTR2 mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.

1. Buscail, L., Saint-Laurent, N., Chastre, E., Vaillant, J. C., Gespach, C., Capella, G., Kalthoff, H., Lluis, F., Vaysse, N., Susini, C.Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer.Cancer Res. 56: 1823-1827, 1996. 2. Filopanti, M., Ronchi, C., Ballare, E., Bondioni, S., Lania, A. G., Losa, M., Gelmini, S., Peri, A., Orlando, C., Beck-Peccoz, P., Spada, A.Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly.J. Clin. Endocr. Metab. 90: 4824-4828, 2005. 3. Guillermet, J., Saint-Laurent, N., Rochaix, P., Cuvillier, O., Levade, T., Schally, A. V., Pradayrol, L., Buscail, L., Susini, C., Bousquet, C.Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis.Proc. Nat. Acad. Sci. 100: 155-160, 2003.

SSTR2

Somatostatin receptor type 2(SS-2-R/SS2-R/SS2R)

somatostatin receptor 2

Somatostatin receptor type 2 antibody SRIF-1 antibody SRIF1 antibody SS-2-R antibody SS2-R antibody SS2R antibody SSR2_HUMAN antibody SST2 antibody SSTR2 antibody

P30874