Anti-NUR77 Antibody | Boster Immunoleader PA1676 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-NUR77 Antibody

catalog :

PA1676

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

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product information

Product Name :

Anti-NUR77 Antibody

Catalog Number :

PA1676

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Nuclear receptor subfamily 4 group A member 1(NR4A1) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human Predicted to work with: mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human NUR77(99-112aa ASFKFEDFQVYGCY), identical to the related rat and mouse sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

NR4A1(NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1), also called NAK1, GFRP1, TR3, NUR77 or NGFIB, is a protein that in humans is encoded by the NR4A1 gene, which is also a member of the Nur nuclear receptor family of intracellular transcription factors. The NR4A1 gene is mapped on 12q13.13. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. It plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells. Nr4a1 was overexpressed in Wnt1 -transformed mouse mammary cells. Nr4a1 was also induced by lithium, a Wnt1 mimic, and the Nr4a1 promoter was activated by lithium and beta-catenin, a Wnt1 downstream effector. In contrast, human NR4A1 was not upregulated by beta-catenin, indicating that this gene is regulated differently in human and mouse cells. Adenoviral expression of Nr4a1 induced genes involved in gluconeogenesis, stimulated glucose production both in vitro and in vivo, and raised blood glucose levels.

Reference :

1. Chang, C., Kokontis, J., Liao, S. S., Chang, Y. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. J. Steroid Biochem. 34: 391-395, 1989. 2. Dequiedt, F., Kasler, H., Fischle, W., Kiermer, V., Weinstein, M., Herndier, B. G., Verdin, E. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 18: 687-698, 2003. 3. Forman, B. M., Umesono, K., Chen, J., Evans, R. M. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81: 541-550, 1995.

Gene Name :

NR4A1

Protein Name :

Nuclear receptor subfamily 4 group A member 1

Gene Full Name :

nuclear receptor subfamily 4, group A, member 1

Synonyms :

Early response protein NAK1 antibody GFRP 1 antibody GFRP antibody GFRP1 antibody Growth factor inducible nuclear protein N10 antibody Growth Factor Inducible Nuclear Protein NP10 antibody Growth Factor Response Protein 1 antibody Hbr1 antibody HMR antibody Hormone Receptor antibody MGC9485 antibody N10 antibody N10 nuclear protein antibody NAK 1 antibody NAK1 antibody Nerve growth factor IB nuclear receptor variant 1 antibody NGFIB antibody NP 10 antibody NP10 antibody NR4A1 antibody NR4A1_HUMAN antibody Nuclear hormone receptor NUR/77 antibody Nuclear Hormone Receptor TR3 antibody Nuclear Receptor Subfamily 4 Group A Member 1 antibody NUR 77 antibody NUR77 antibody Orphan nuclear receptor HMR antibody Orphan nuclear receptor NR4A1 antibody Orphan nuclear receptor TR3 antibody ST 59 antibody ST-59 antibody ST59 antibody Steroid receptor TR3 antibody Testicular receptor 3 antibody TR 3 antibody TR3 antibody TR3 orphan receptor antibody

Uniprot ID :

P22736

more info or order :

Boster Immunoleader product webpage