Boster Immunoleader

antibody

Anti-Podoplanin/gp36 Antibody

PA1674

100 ug/vial

200 USD

polyclonal

rabbit

Anti-Podoplanin/gp36 Antibody

PA1674

Polyclonal

Rabbit IgG polyclonal antibody for Podoplanin(PDPN) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human Podoplanin/gp36(227-238aa VVMRKMSGRYSP).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

PDPN(Podoplanin), also called T1A, T1A2, GP36, OTS8 or AGGRUS, is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The PDPN gene is mapped to chromosome 1 by the International radiation Hybrid mapping consortium. The physiological function of PDPN may be related to its mucin-type character. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Immunohistochemical analysis of PDPN in placenta, kidney, lung, and nasal polyps showed expression at the apical plasma membrane of vascular endothelial cells and in alveolar epithelial cells. Overexpression of rat PDPN in human and rodent endothelial cells promoted formation of elongated cell extensions and significantly increased endothelial cell adhesion, migration, and tube formation. Inhibition of PDPN expression by small interfering RNAs decreased cell adhesion in cultured human dermal lymphatic endothelial cells.

1. Kato, Y., Fujita, N., Kunita, A., Sato, S., Kaneko, M., Osawa, M., Tsuruo, T. Molecular identification of Aggrus/T1-alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J. Biol. Chem. 278: 51599-51605, 2003. 2. Ma, T., Yang, B., Matthay, M. A., Verkman, A. S. Evidence against a role of mouse, rat, and two cloned human T1-alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am. J. Resp. Cell Molec. Biol. 19: 143-149, 1998. 3. Schacht, V., Ramirez, M. I., Hong, Y.-K., Hirakawa, S., Feng, D., Harvey, N., Williams, M., Dvorak, A. M., Dvorak, H. F., Oliver, G., Detmar, M. T1-alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 22: 3546-3556, 2003.

PDPN

Podoplanin

podoplanin

AGGRUS antibody GLYCOPROTEIN 36 KD antibody Glycoprotein 36 antibody gp 36 antibody GP 38 antibody GP 40 antibody gp36 antibody GP38 antibody GP40 antibody HT1A 1 antibody HT1A1 antibody hT1alpha1 antibody hT1alpha2 antibody Lung type I cell membrane associated glycoprotein antibody Lung type I cell membrane associated glycoprotein isoform a antibody Lung type I cell membrane associated glycoprotein T1A 2 antibody OTS 8 antibody OTS8 antibody OTTHUMP00000009640 antibody OTTHUMP00000044504 antibody PA2.26 antibody PA2.26 antigen antibody PDPN antibody PDPN_HUMAN antibody Podoplanin antibody PSEC0003 antibody PSEC0025 antibody T1 alpha antibody T1 ALPHA GENE antibody T1-alpha antibody T1A 2 antibody T1A antibody TIA 2 antibody TIA2 antibody

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